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Survival outcome among patients with Ewing's sarcoma of bones and joints: a population-based cohort study.
Wan, Zi-Hao; Huang, Zhi-Hao; Chen, Liao-Bin.
Afiliação
  • Wan ZH; MD, MSc. Surgeon, Department of Orthopedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
  • Huang ZH; MD, MSc. Surgeon, Department of Colorectal and Anal Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
  • Chen LB; MD. Surgeon, Department of Orthopedic Surgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
Sao Paulo Med J ; 136(2): 116-122, 2018.
Article em En | MEDLINE | ID: mdl-29267540
BACKGROUND: The aim here was to elucidate the current survival condition of patients diagnosed with Ewing's sarcoma of the bones and joints and determine independent risk factors associated with the prognosis. DESIGN AND SETTING: Retrospective cohort study based on the Surveillance, Epidemiology and End Results (SEER) database in the United States. METHODS: We identified 397 patients who were diagnosed with Ewing's sarcoma of the bones and joints between January 2004 and December 2013. The multivariate Cox proportional hazards model was used to determine factors associated with the risk of death by adjusting for various factors. RESULTS: The one, two and five-year disease-specific survival rates were 89.08%, 78.08% and 62.47%, respectively. The factors related to death were age (≥ 18 years versus < 18 years; hazard ratio, HR = 1.77; 95% confidence interval, CI: 1.38-2.31); tumor site (extremity versus spine and pelvis; HR = 2.03; 95% CI: 1.31-2.62); tumor size (> 10 cm versus ≤ 10 cm; HR = 1.78; 95% CI: 1.34-2.56); and type of treatment (surgery alone versus radiotherapy with surgery; HR = 0.51; 95% CI: 0.38-0.89; or radiotherapy alone versus radiotherapy with surgery; HR = 1.61; 95% CI: 1.10-2.39; or no treatment versus radiotherapy with surgery; HR = 1.86; 95% CI: 1.23, 2.58). CONCLUSIONS: Patients with Ewing's sarcoma showed poor survival in situations of age ≥ 18 years, tumor size > 10 cm, receiving radiotherapy alone and receiving no treatment. Patients undergoing surgery alone had better survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing / Neoplasias Ósseas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sao Paulo Med J Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcoma de Ewing / Neoplasias Ósseas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sao Paulo Med J Assunto da revista: MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Brasil