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One-Pot Aqueous Synthesis of Fluorescent Ag-In-Zn-S Quantum Dot/Polymer Bioconjugates for Multiplex Optical Bioimaging of Glioblastoma Cells.
Mansur, Alexandra A P; Mansur, Herman S; Carvalho, Sandhra M; Caires, Anderson J.
Afiliação
  • Mansur AAP; Center of Nanoscience, Nanotechnology and Innovation (CeNanoI), Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
  • Mansur HS; Center of Nanoscience, Nanotechnology and Innovation (CeNanoI), Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
  • Carvalho SM; Center of Nanoscience, Nanotechnology and Innovation (CeNanoI), Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
  • Caires AJ; Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Contrast Media Mol Imaging ; 2017: 3896107, 2017.
Article em En | MEDLINE | ID: mdl-29259535
Cancer research has experienced astonishing advances recently, but cancer remains a major threat because it is one of the leading causes of death worldwide. Glioblastoma (GBM) is the most malignant brain tumor, where the early diagnosis is vital for longer survival. Thus, this study reports the synthesis of novel water-dispersible ternary AgInS2 (AIS) and quaternary AgInS2-ZnS (ZAIS) fluorescent quantum dots using carboxymethylcellulose (CMC) as ligand for multiplexed bioimaging of malignant glioma cells (U-87 MG). Firstly, AgInS2 core was prepared using a one-pot aqueous synthesis stabilized by CMC at room temperature and physiological pH. Then, an outer layer of ZnS was grown and thermally annealed to improve their optical properties and split the emission range, leading to core-shell alloyed nanostructures. Their physicochemical and optical properties were characterized, demonstrating that luminescent monodispersed AIS and ZAIS QDs were produced with average sizes of 2.2 nm and 4.3 nm, respectively. Moreover, the results evidenced that they were cytocompatible using in vitro cell viability assays towards human embryonic kidney cell line (HEK 293T) and U-87 MG cells. These AIS and ZAIS successfully behaved as fluorescent nanoprobes (red and green, resp.) allowing multiplexed bioimaging and biolabeling of costained glioma cells using confocal microscopy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Pontos Quânticos Tipo de estudo: Screening_studies Limite: Humans Idioma: En Revista: Contrast Media Mol Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Pontos Quânticos Tipo de estudo: Screening_studies Limite: Humans Idioma: En Revista: Contrast Media Mol Imaging Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido