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IMMUNOMODULATING EFFECTS OF THE PURIFIED HEV B 13 FRACTION ON SEPTIC RATS.
Alves, Maxley Martins; Araújo, Lilhian Alves de; Mrué, Fátima; Gomes, Clayson Moura; Oliveira, Milton Adriano Pelli de; Neves, Roberpaulo Anacleto; Silva-Júnior, Nelson Jorge da; Melo-Reis, Paulo Roberto de.
Afiliação
  • Alves MM; Laboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
  • Araújo LA; Laboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
  • Mrué F; Laboratory of Cytokines, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.
  • Gomes CM; Laboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
  • Oliveira MAP; Laboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
  • Neves RA; Laboratory of Cytokines, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.
  • Silva-Júnior NJD; Laboratory of Cytokines, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, Brazil.
  • Melo-Reis PR; Laboratory of Experimental and Biotechnological Studies of the Post-Graduate Program in Environmental Sciences and Health, Area V, Campus I, Pontifical Catholic University of Goiás.
Arq Bras Cir Dig ; 30(2): 93-97, 2017.
Article em En, Pt | MEDLINE | ID: mdl-29257842
BACKGROUND: Sepsis is a potentially life-threatening complication of an infection that occurs when chemicals released into the bloodstream to fight the infection trigger inflammatory responses throughout the body, especially in the acute phase of the disease, producing excessive pro-inflammatory cytokines, leading to multiple organ injury and death. The Hev b 13 fraction has demonstrated biological activity capable of inducing IL-10 production and shrinking inflammatory disease lesions. AIM: To investigate the immunomodulating effects of the Hev b 13 fraction on septic rats. METHODS: Acinetobacter baumannii was injected into the peritoneal cavity of the animals after sustaining a lesion in the pancreas, with the stomach as an entry point. After 10 h of infection, they were euthanized for blood and lung collection, followed by total and differential leukocyte count, determination of cytokine level and histopathological analysis. RESULTS: Administering a single dose of the Hev b 13 fraction 2 h after sepsis induction significantly decreased total leukocyte count. Higher IL-10 and IL-4 and lower IL-6 production shrank the lung tissue lesions compared to the control groups. CONCLUSION: The Hev b 13 fraction exhibits an anti-inflammatory tendency, with potential for sepsis treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Plantas / Sepse / Antígenos de Plantas / Imunomodulação / Fitoterapia Limite: Animals Idioma: En / Pt Revista: Arq Bras Cir Dig Ano de publicação: 2017 Tipo de documento: Article País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Plantas / Sepse / Antígenos de Plantas / Imunomodulação / Fitoterapia Limite: Animals Idioma: En / Pt Revista: Arq Bras Cir Dig Ano de publicação: 2017 Tipo de documento: Article País de publicação: Brasil