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Lack of association between serum syndecan-4, myocardial fibrosis and ventricular dysfunction in subjects with chronic Chagas disease.
Larocca, Ticiana Ferreira; Macêdo, Carolina Thé; Noya-Rabelo, Márcia; Lemos Correia, Luís Cláudio; Moreira, Moisés Imbassahy; Caldas, Alessandra Carvalho; Torreão, Jorge Andion; Souza, Bruno Solano de Freitas; Vasconcelos, Juliana Fraga; Carvalho da Silva, Alexandre Schaer; Ribeiro Dos Santos, Ricardo; Soares, Milena Botelho Pereira.
Afiliação
  • Larocca TF; Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Macêdo CT; Gonçalo Moniz Institute, IGM-Fiocruz/BA, Salvador, Bahia, Brazil.
  • Noya-Rabelo M; Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Lemos Correia LC; Department of Cardiology, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Moreira MI; Department of Cardiology, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Caldas AC; Department of Cardiology, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Torreão JA; Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.
  • Souza BSF; Department of Cardiology, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Vasconcelos JF; Department of Cardiology, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Carvalho da Silva AS; Department of Cardiology, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Ribeiro Dos Santos R; Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Bahia, Brazil.
  • Soares MBP; Gonçalo Moniz Institute, IGM-Fiocruz/BA, Salvador, Bahia, Brazil.
PLoS One ; 12(12): e0189408, 2017.
Article em En | MEDLINE | ID: mdl-29232393
BACKGROUND: Syndecan-4 is a transmembrane glycoprotein associated with inflammation and fibrosis. Increased syndecan-4 levels were previously detected after acute myocardial infarction and in subjects with heart failure. However, the levels of syndecan-4 in subjects with Chagas disease have not so far been investigated. The aim of this study was to investigate the potential role of serum sydencan-4 as a novel biomarker for myocardial fibrosis and cardiac dysfunction in subjects with Chagas disease. METHODS: This study comprised subjects with Chagas disease (n = 56), being 14 (25%) with the indeterminate form, 16 (29%) with the cardiac form without ventricular dysfunction, and 26 (46%) with the cardiac form with ventricular dysfunction. RESULTS: Syndecan-4 serum concentrations did not correlate with presence or absence of myocardial fibrosis (P = 0.386) nor disease severity in subjects with Chagas disease (P = 0.918). Additionally, no correlation was found either between the degree of myocardial fibrosis and serum syndecan-4 [r = 0.08; P = 0.567] or between left ventricular ejection fraction and syndecan-4 [r = 0.02; P = 0.864]. In contrast, NT-proBNP levels correlated with ejection fraction and myocardial fibrosis. CONCLUSIONS: Our results demonstrate the lack of correlations between serum syndecan-4, myocardial fibrosis and cardiac dysfunction in subjects with Chagas disease. Further studies are required to show if syndecan-4 concentrations can be marker for prognosis assessment or disease progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Doença de Chagas / Sindecana-4 / Cardiomiopatias Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrose / Doença de Chagas / Sindecana-4 / Cardiomiopatias Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos