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Social-demographics, health behaviors, and telomere length in the Mexican American Mano a Mano Cohort.
Zhao, Hua; Han, Lixia; Chang, David; Ye, Yuanqing; Shen, Jie; Daniel, Carrie R; Gu, Jian; Chow, Wong-Ho; Wu, Xifeng.
Afiliação
  • Zhao H; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Han L; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chang D; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ye Y; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Shen J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Daniel CR; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Gu J; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Chow WH; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wu X; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Oncotarget ; 8(57): 96553-96567, 2017 Nov 14.
Article em En | MEDLINE | ID: mdl-29228552
In the current study, we examined cross-sectional associations among social-demographics, lifestyle behaviors, and relative telomere length (RTL) in peripheral blood leukocytes, as well as longitudinal relationships among major chronic diseases, weight gain, and RTL, among 12,792 Mexican Americans aged 20 to 85 years in the Mano-A-Mano, the Mexican American Cohort. As expected, RTL was inversely correlated with age (ρ=-0.15, ρ<0.001). In the multivariate analysis, we found that RTL was positively correlated with levels of education (ρ=0.021), self-insurance (ρ=0.041), body mass index (BMI) (ρ<0.001), and sleeping time per day (ρ for trend<0.001), and RTL was inversely correlated with sitting time per day (ρ for trend =0.001). In longitudinal analysis, we found that longer RTL was modestly but positively associated with increased risks of overall cancer (adjusted hazard ratio (adj.HR)=1.05, 95% conference interval (95%CI)=1.02-1.09). In quartile analysis, 4th quartile (longest RTL) was associated with 1.53-fold increased risk of overall cancer (adj.HR=1.53, 95%CI=1.11-2.10), compared to 1st quartile (shortest RTL). RTL was reversely associated with the risk of type-2 diabetes (adj.HR=0.89, 95%CI=0.82-0.94). In quartile analysis, 4th quartile (longest RTL) was associated with 48% decreased risk of typle-2 diabetes (adj.HR=0.52, 95%CI=0.32-0.70), compared to 1st quartile (shortest RTL). In addition, longer RTL was a positive predictor of at least 10% weight gain (adj.HR=1.03, 95%CI=1.00-1.05). In summary, our results in Mexican Americans support the notion that telomere length is a biological mechanism by which social demographics and health behaviors "get under the skin" to affect health.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies País/Região como assunto: Mexico Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies País/Região como assunto: Mexico Idioma: En Revista: Oncotarget Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos