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Evaluation of seven rapid tests for syphilis available in Brazil using defibrinated plasma panels.
Bazzo, Maria Luiza; da Motta, Leonardo Rapone; Rudolf-Oliveira, Renata Cristina Messores; Bigolin, Alisson; Golfetto, Lisléia; Mesquita, Fábio; Benzaken, Adele Schwartz; Gaspar, Pamela Cristina; Pires, Ana Flavia Nacif P Coelho; Ferreira Júnior, Orlando da Costa; Franchini, Miriam.
Afiliação
  • Bazzo ML; Department of Clinical Analysis, Health Sciences Center, Laboratory of Molecular Biology, Microbiology and Serology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
  • da Motta LR; Research Laboratory on HIV/AIDS, Center for Life Sciences and Health, University of Caxias do Sul, Rua Francisco Getúlio Vargas, Caxias do Sul, Brazil.
  • Rudolf-Oliveira RCM; Department of Clinical Analysis, Health Sciences Center, Laboratory of Molecular Biology, Microbiology and Serology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
  • Bigolin A; Department of Clinical Analysis, Health Sciences Center, Laboratory of Molecular Biology, Microbiology and Serology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
  • Golfetto L; Department of Clinical Analysis, Health Sciences Center, Laboratory of Molecular Biology, Microbiology and Serology, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
  • Mesquita F; Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
  • Benzaken AS; Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Setor Administrativo Federal Sul, Brasília, Distrito Federal, Brazil.
  • Gaspar PC; Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Setor Administrativo Federal Sul, Brasília, Distrito Federal, Brazil.
  • Pires AFNPC; Department of Surveillance, Prevention and Control of Sexually Transmitted Infections, HIV/AIDS and Viral Hepatitis, Secretariat of Health Surveillance, Ministry of Health, Setor Administrativo Federal Sul, Brasília, Distrito Federal, Brazil.
  • Ferreira Júnior ODC; Faculdade de Medicina, Faculdade de Ciências de Saúde, Programa de Pós Graduação em Saúde Coletiva, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Brasília, Distrito Federal, Brazil.
  • Franchini M; Laboratory of Molecular Virology, Institute of Biology, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, Rio de Janeiro, Brazil.
Sex Transm Infect ; 93(S4): S46-S50, 2017 12.
Article em En | MEDLINE | ID: mdl-29223962
OBJECTIVES: In 2012, the WHO estimated that 6 million new cases of syphilis per year would occur worldwide, including 937 000 in Brazil. Early diagnosis and treatment of syphilis are essential to reduce morbidity and prevent transmission. The availability of rapid tests (RTs) for this diagnosis means that testing can be performed more quickly, as a point-of-care test, even in non-laboratory environments and requires only simple technical training to antibodies detection. The objective of this study was to evaluate the performance and operational aspects of seven commercially available RTs for syphilis in Brazil. METHODS: Seven rapid treponemal tests were evaluated for sensitivity, specificity, accuracy and Kappa value, according to a panel composed of 493 members. The operational performance of the assay was also determined for these tests. RESULTS: The seven RTs showed sensitivity ranging from 94.5% to 100% when compared with the reference tests and specificity of between 91.5% and 100%. All the RTs evaluated presented good operational performance, and only one failed to present the minimum specificity as defined by Brazil's Ministry of Health. CONCLUSION: All the tests presented good operational performance, and the professionals who performed them considered them to be easy to use and interpret. This evaluation is important for making informed choices of tests to be used in the Brazilian Unified Health System.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treponema pallidum / Fibrina / Sífilis / Programas de Rastreamento Tipo de estudo: Diagnostic_studies / Evaluation_studies / Prognostic_studies / Screening_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sex Transm Infect Assunto da revista: DOENCAS SEXUALMENTE TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Treponema pallidum / Fibrina / Sífilis / Programas de Rastreamento Tipo de estudo: Diagnostic_studies / Evaluation_studies / Prognostic_studies / Screening_studies Limite: Adult / Female / Humans / Male País/Região como assunto: America do sul / Brasil Idioma: En Revista: Sex Transm Infect Assunto da revista: DOENCAS SEXUALMENTE TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido