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Arsenic Exposure in Relation to Ischemic Stroke: The Reasons for Geographic and Racial Differences in Stroke Study.
Tsinovoi, Cari L; Xun, Pengcheng; McClure, Leslie A; Carioni, Vivian M O; Brockman, John D; Cai, Jianwen; Guallar, Eliseo; Cushman, Mary; Unverzagt, Frederick W; Howard, Virginia J; He, Ka.
Afiliação
  • Tsinovoi CL; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Xun P; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • McClure LA; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Carioni VMO; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Brockman JD; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Cai J; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Guallar E; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Cushman M; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Unverzagt FW; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • Howard VJ; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
  • He K; From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.) and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.); University of Missouri Research Reactor Center, University of Missouri, Co
Stroke ; 49(1): 19-26, 2018 01.
Article em En | MEDLINE | ID: mdl-29212736
BACKGROUND AND PURPOSE: The purpose of this case-cohort study was to examine urinary arsenic levels in relation to incident ischemic stroke in the United States. METHODS: We performed a case-cohort study nested within the REGARDS (REasons for Geographic and Racial Differences in Stroke) cohort. A subcohort (n=2486) of controls was randomly sampled within region-race-sex strata while all incident ischemic stroke cases from the full REGARDS cohort (n=671) were included. Baseline urinary arsenic was measured by inductively coupled plasma-mass spectrometry. Arsenic species, including urinary inorganic arsenic and its metabolites monomethylarsonic acid and dimethylarsinic acid, were measured in a random subset (n=199). Weighted Cox's proportional hazards models were used to calculate hazard ratios and 95% confidence intervals of ischemic stroke by arsenic and its species. RESULTS: The average follow-up was 6.7 years. Although incident ischemic stroke showed no association with total arsenic or total inorganic arsenic, for each unit higher level of urinary monomethylarsonic acid on a log-scale, after adjustment for potential confounders, ischemic stroke risk increased ≈2-fold (hazard ratio=1.98; 95% confidence interval: 1.12-3.50). Effect modification by age, race, sex, or geographic region was not evident. CONCLUSIONS: A metabolite of arsenic was positively associated with incident ischemic stroke in this case-cohort study of the US general population, a low-to-moderate exposure area. Overall, these findings suggest a potential role for arsenic methylation in the pathogenesis of stroke, having important implications for future cerebrovascular research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Arsenicais / Isquemia Encefálica / Acidente Vascular Cerebral Tipo de estudo: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Stroke Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Arsenicais / Isquemia Encefálica / Acidente Vascular Cerebral Tipo de estudo: Clinical_trials / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do norte Idioma: En Revista: Stroke Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos