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Safety and Feasibility Study of a Novel Stent-Graft for Thoracic Endovascular Aortic Repair: a Canine Model Experiment.
Yang, Fan; Qiu, Jiehua; Fu, Zeliang; Qiu, Yuchen; Luo, Junrong; Xiao, Qingyang; Cao, Huabin.
Afiliação
  • Yang F; Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agriculture University, Jiangxi, P.R. China.
  • Qiu J; Department of Vascular Surgery, the Second Affiliated Hospital of Nanchang University, Jiangxi, P.R. China.
  • Fu Z; APT Medical Inc., Hunan, P.R. China.
  • Qiu Y; APT Medical Inc., Hunan, P.R. China.
  • Luo J; Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agriculture University, Jiangxi, P.R. China.
  • Xiao Q; Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agriculture University, Jiangxi, P.R. China.
  • Cao H; Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agriculture University, Jiangxi, P.R. China.
Braz J Cardiovasc Surg ; 32(5): 401-407, 2017.
Article em En | MEDLINE | ID: mdl-29211221
OBJECTIVE: To evaluate the safety and feasibility of a novel stent-graft for thoracic endovascular aortic repair (TEVAR) in a canine model, 9 adult hybrid dogs were used for the experiment. METHODS: All animals were implanted with a novel thoracic aortic stent-graft via femoral artery. Blood sample was collected at pre-operation and 1, 2, 4, 8 and 12 weeks after implantation for hematological examination. Moreover, tissues from randomly selected 4 dogs were subjected to histopathological analysis with the optical microscope after stent-grafts were implanted for 3, 6, 9, and 12 months respectively. The experimental period lasted for more than 2 years. RESULTS: A total of 9 stent-grafts were successfully implanted in the canine thoracic aortas and no migration or deformation occurred. Related indicators of blood routine, inflammatory factors, and immunology changes were not significantly (P>0.05), except the white blood cell (WBC) counts in the first week. Moreover, abnormal morphology was not found in all thoracic aortas via histopathological examination. Additionally, all stent-grafts were patent and did not migrate, and there was no thrombus in the lumens of stent-grafts. CONCLUSION: The novel thoracic aortic stent-graft made in China was safe and feasible for thoracic endovascular aortic repair in a canine model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Torácica / Stents / Implante de Prótese Vascular / Procedimentos Endovasculares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz J Cardiovasc Surg Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Torácica / Stents / Implante de Prótese Vascular / Procedimentos Endovasculares Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz J Cardiovasc Surg Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Brasil