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ß-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method.
Oliveira, Davi Rocha Bernardes; Michelon, Mariano; de Figueiredo Furtado, Guilherme; Sinigaglia-Coimbra, Rita; Cunha, Rosiane Lopes.
Afiliação
  • Oliveira DRB; Department of Food Engineering, Faculty of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
  • Michelon M; Department of Food Engineering, Faculty of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
  • de Figueiredo Furtado G; Department of Food Engineering, Faculty of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil.
  • Sinigaglia-Coimbra R; Center Electron Microscopy, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), 04023-062 São Paulo, SP, Brazil.
  • Cunha RL; Department of Food Engineering, Faculty of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, SP, Brazil. Electronic address: rosiane@unicamp.br.
Food Res Int ; 90: 139-146, 2016 Dec.
Article em En | MEDLINE | ID: mdl-29195866
Tristearin solid lipid nanoparticles and tristearin/high oleic sunflower oil nanostructured lipid carriers were produced by solvent displacement method. All conditions allowed forming polydisperse particles within nanometric range and the presence of high oleic sunflower oil did not affect the particles mean size. Nevertheless, incorporation of ß-carotene reduced the particles polydispersity. Thermograms of solid lipid nanoparticles and nanostructured lipid carriers showed that sunflower oil generated a crystal order disturbance, since nanoparticles with less-organized lipid matrix were produced. Nanostructured lipid carriers exhibited an improvement of ß-carotene loading capacity when compared with solid lipid nanoparticles, which enhanced with the increasing of high oleic sunflower oil content. Although total ß-carotene degradation was similar for all systems, color analysis showed that the degradation of encapsulated ß-carotene was lower for high sunflower oil content. Nanostructured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Food Res Int Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Food Res Int Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Canadá