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Effect of simvastatin on sensorial, motor, and morphological parameters in sciatic nerve crush induced-neuropathic pain in rats.
Corso, Claudia Rita; Martins, Daniel Fernandes; Borges, Stephanie Carvalho; Beltrame, Olair Carlos; Telles, José Ederaldo Queiroz; Buttow, Nilza Cristina; Werner, Maria Fernanda de Paula.
Afiliação
  • Corso CR; Department of Pharmacology, (UFPR), Biological Science Sector, Federal University of Parana, PO Box 19031, Curitiba, PR, 81531-980, Brazil.
  • Martins DF; Post-Graduate Program in Health Science, UNISUL, Palhoça, SC, Brazil.
  • Borges SC; Department of Morphological Sciences, State University of Maringa, Maringa, PR, Brazil.
  • Beltrame OC; Department of Veterinary Medicine, Federal University of Parana, Curitiba, PR, Brazil.
  • Telles JEQ; Department of Medical Pathology, Federal University of Parana, Curitiba, PR, Brazil.
  • Buttow NC; Department of Morphological Sciences, State University of Maringa, Maringa, PR, Brazil.
  • Werner MFP; Department of Pharmacology, (UFPR), Biological Science Sector, Federal University of Parana, PO Box 19031, Curitiba, PR, 81531-980, Brazil. mfernanda.werner@ufpr.br.
Inflammopharmacology ; 26(3): 793-804, 2018 Jun.
Article em En | MEDLINE | ID: mdl-29188473
The present study compares the effects of a low and high doses of simvastatin in a model of peripheral neuropathy by evaluating sensorial, motor, and morphological parameters. First, male Wistar rats were orally treated with vehicle (saline, 1 mL/kg), simvastatin (2 and 80 mg/kg) or morphine (2 mg/kg, s.c.), 1 h before 2.5% formalin injection. Neuropathic pain was induced by crushing the sciatic nerve, and mechanical and cold allodynia, nerve function, histology, MPO and NAG concentrations, as well as mevalonate induced-nociception were evaluated. Animals were orally treated with vehicle, simvastatin, or gabapentin (30 mg/kg) for 18 days. Simvastatin (2 and 80 mg/kg) reduced the inflammatory pain induced by formalin, but failed to decrease the paw edema. Mechanical allodynia was reduced by the simvastatin (2 mg/kg) until the 12th day after injury and until the 18th day by gabapentin. However, both simvastatin and gabapentin treatments failed in attenuated cold allodynia or improved motor function. Interestingly, both doses of simvastatin showed a neuroprotective effect and inhibited MPO activity without altering kidney and hepatic parameters. Additionally, only the higher dose of simvastatin reduced the cholesterol levels and the nociception induced by mevalonate. Our results reinforce the antinociceptive, antiallodynic, and anti-inflammatory effects of oral simvastatin administration, which can strongly contribute to the sciatic nerve morphology preservation. Furthermore, our data suggest that lower and higher doses of simvastatin present beneficial effects that are dependent and independent of the mevalonate pathway, respectively, without causing signs of nerve damage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medição da Dor / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Neuropatia Ciática / Hiperalgesia / Neuralgia Limite: Animals Idioma: En Revista: Inflammopharmacology Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medição da Dor / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Neuropatia Ciática / Hiperalgesia / Neuralgia Limite: Animals Idioma: En Revista: Inflammopharmacology Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça