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Radium-223 IN metastatic hormone-sensitive high-grade prostate cancer: initial experience.
Osvaldo, García-Pérez Francisco; Salvador, Medina-Ornelas Sevastián; Zael, Santana-Ríos; Nora, Sobrevilla-Moreno.
Afiliação
  • Osvaldo GF; Nuclear Medicine and Molecular Imaging Department, Instituto Nacional de CancerologíaMexico City, Mexico.
  • Salvador MS; Nuclear Medicine and Molecular Imaging Department, Instituto Nacional de CancerologíaMexico City, Mexico.
  • Zael SR; Urologic Malignances Department, Instituto Nacional de CancerologíaMexico City, Mexico.
  • Nora SM; Oncology Department, Instituto Nacional de CancerologíaMexico City, Mexico.
Am J Nucl Med Mol Imaging ; 7(5): 236-245, 2017.
Article em En | MEDLINE | ID: mdl-29181271
Our study evaluates the feasibility of compassionate exemption of Radium-223 (223Ra) treatment in metastatic hormone-sensitive high-grade prostate cancer (mHSHGPC) patients with concomitant androgen deprivation-therapy (ADT). Seven patients with mHSHGPC, were treated with six cycles of 223Ra plus ADT. All patients had undergone to 18F-NaF-PET/CT. A qualitative analyses of the 18F-NaF-PET/CT was performed in conjunction with Alkaline Phosphatase (ALP), Lactate-dehydrogenase (LDH) and Prostatic-Specific Antigen (PSA) values. The mean of SUVmax values were used as a quantitative measure of tumoral burden. Changes in PSA, ALP, LDH from baseline were evaluated, and were defined as increase or decrease of at least 30%. Clinical response was achieved if there was pain reduction using visual analogic scale. Four patients showed a significant reduction in mean SUVmax after 3 cycles of 223Ra, and one after 6 cycles. Patients who showed reductions in mean SUVmax after Ra-223 also showed reductions in PSA, ALP and LDH. Four weeks after the last cycle of 223Ra all patients had decreased total PSA, ALP and LDH values ≥ 30% also significant improvement on pain. No progress disease was documented after 14 ± 4 weeks. We found slight to moderate decreases in neutrophils and hemoglobin in two patients. We concluded that 223Ra plus ADT can be useful in mHSHGPC; the semi-quantitative 18F-NaF-PET/CT as a method effective to monitor the treatment response. Due to concomitant administration of ADT, 18F-NaF-PET/CT cannot differentiate whether the findings were due to androgen blockade or the 223Ra; nevertheless, data supporting the efficacy of 223Ra is the significant improvement on pain.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Qualitative_research Idioma: En Revista: Am J Nucl Med Mol Imaging Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Qualitative_research Idioma: En Revista: Am J Nucl Med Mol Imaging Ano de publicação: 2017 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos