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Omega-3 fatty acids, inflammatory status and biochemical markers of patients with systemic lupus erythematosus: a pilot study.
Curado Borges, Mariane; de Miranda Moura Dos Santos, Fabiana; Weiss Telles, Rosa; Melo de Andrade, Marcus Vinícius; Toulson Davisson Correia, Maria Isabel; Lanna, Cristina Costa Duarte.
Afiliação
  • Curado Borges M; Secretaria de Estado de Saúde do Distrito Federal, Coordenação Geral de Saúde da Criança e Aleitamento Materno (CGSCAM), Brasilia, DF, Brazil.
  • de Miranda Moura Dos Santos F; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento do Aparelho Locomotor, Belo Horizonte, MG, Brazil.
  • Weiss Telles R; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte, MG, Brazil.
  • Melo de Andrade MV; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte, MG, Brazil.
  • Toulson Davisson Correia MI; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Cirurgia, Belo Horizonte, MG, Brazil.
  • Lanna CCD; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento do Aparelho Locomotor, Belo Horizonte, MG, Brazil. Electronic address: duartelanna@gmail.com.
Rev Bras Reumatol Engl Ed ; 57(6): 526-534, 2017.
Article em En, Pt | MEDLINE | ID: mdl-29173690
BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. OBJECTIVE: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). METHODS: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group. The inflammatory mediators and biochemical markers at T0 and T1 in omega-3 group were compared using Wilcoxon test. U-Mann-Whitney test was used to compare variations of measured variables [ΔV=pre-treatment (T0)-post-treatment (T1) concentrations] between groups. p<0.05 was considered significant. RESULTS: The median (interquartile range - IQR) of age was 37 (29-48) years old, of disease duration was 7 (4-13) years, and of SLEDAI-2K was 1 (0-2). The median (IQR) of variation in CRP levels between the two groups showed a decrease in omega-3 group while there was an increase in control group (p=0.008). The serum concentrations of IL-6 and IL-10, leptin and adiponectin did not change after a 12 week treatment. CONCLUSIONS: Supplementation with omega-3 had no impact on serum concentrations of IL-6, IL-10, leptin and adiponectin in women with SLE and low disease activity. There was a significant decrease of CRP levels as well as evidence that omega-3 may impact total and LDL-cholesterol.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Ácidos Graxos Ômega-3 / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Middle aged Idioma: En / Pt Revista: Rev Bras Reumatol Engl Ed Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Ácidos Graxos Ômega-3 / Lúpus Eritematoso Sistêmico Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Middle aged Idioma: En / Pt Revista: Rev Bras Reumatol Engl Ed Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil