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The 17D-204 and 17DD yellow fever vaccines: an overview of major similarities and subtle differences.
Ferreira, Clarissa de Castro; Campi-Azevedo, Ana Carolina; Peruhype-Magalhaes, Vanessa; Costa-Pereira, Christiane; Albuquerque, Cleandro Pires de; Muniz, Luciana Feitosa; Yokoy de Souza, Talita; Oliveira, Ana Cristina Vanderley; Martins-Filho, Olindo Assis; da Mota, Licia Maria Henrique.
Afiliação
  • Ferreira CC; a Department of Rheumatology , University Hospital of Brasilia, University of Brasilia , Brasilia , Brazil.
  • Campi-Azevedo AC; b René-Rachou Research Center , FIOCRUZ , Belo Horizonte , Brazil.
  • Peruhype-Magalhaes V; b René-Rachou Research Center , FIOCRUZ , Belo Horizonte , Brazil.
  • Costa-Pereira C; b René-Rachou Research Center , FIOCRUZ , Belo Horizonte , Brazil.
  • Albuquerque CP; a Department of Rheumatology , University Hospital of Brasilia, University of Brasilia , Brasilia , Brazil.
  • Muniz LF; a Department of Rheumatology , University Hospital of Brasilia, University of Brasilia , Brasilia , Brazil.
  • Yokoy de Souza T; a Department of Rheumatology , University Hospital of Brasilia, University of Brasilia , Brasilia , Brazil.
  • Oliveira ACV; a Department of Rheumatology , University Hospital of Brasilia, University of Brasilia , Brasilia , Brazil.
  • Martins-Filho OA; b René-Rachou Research Center , FIOCRUZ , Belo Horizonte , Brazil.
  • da Mota LMH; a Department of Rheumatology , University Hospital of Brasilia, University of Brasilia , Brasilia , Brazil.
Expert Rev Vaccines ; 17(1): 79-90, 2018 01.
Article em En | MEDLINE | ID: mdl-29172832
INTRODUCTION: The yellow fever vaccine is a live attenuated virus vaccine that is considered one of the most efficient vaccines produced to date. The original 17D strain generated the substrains 17D-204 and 17DD, which are used for the current production of vaccines against yellow fever. The 17D-204 and 17DD substrains present subtle differences in their nucleotide compositions, which can potentially lead to variations in immunogenicity and reactogenicity. We will address the main changes in the immune responses induced by the 17D-204 and 17DD yellow fever vaccines and report similarities and differences between these vaccines in cellular and humoral immunity . This is a relevant issue in view of the re-emergence of yellow fever in Uganda in 2016 and in Brazil in the beginning of 2017. AREAS COVERED: This article will be divided into 8 sections that will analyze the innate immune response, adaptive immune response, humoral response, production of cytokines, immunity in children, immunity in the elderly, gene expression and adverse reactions. EXPERT COMMENTARY: The 17D-204 and 17DD yellow fever vaccines present similar immunogenicity, with strong activation of the cellular and humoral immune responses. Additionally, both vaccines have similar adverse effects, which are mostly mild and thus are considered safe.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Amarela / Vacina contra Febre Amarela Limite: Aged / Animals / Child / Humans País/Região como assunto: Africa / America do sul / Brasil Idioma: En Revista: Expert Rev Vaccines Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Amarela / Vacina contra Febre Amarela Limite: Aged / Animals / Child / Humans País/Região como assunto: Africa / America do sul / Brasil Idioma: En Revista: Expert Rev Vaccines Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido