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AgNPs: The New Allies Against S. Mutans Biofilm - A Pilot Clinical Trial and Microbiological Assay.
Freire, Priscila L L; Albuquerque, Allan J R; Sampaio, Fabio C; Galembeck, André; Flores, Miguel A P; Stamford, Thayza C M; Rosenblatt, Aronita.
Afiliação
  • Freire PLL; FOP - Faculdade de Odontologia de Pernambuco, UPE - Universidade de Pernambuco, Recife, PE, Brazil.
  • Albuquerque AJR; UFPB - Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
  • Sampaio FC; UFPB - Universidade Federal da Paraíba, João Pessoa, PB, Brazil.
  • Galembeck A; UFPE - Universidade Federal de Perna mbuco, Recife, PE, Brazil.
  • Flores MAP; UFPE - Universidade Federal de Perna mbuco, Recife, PE, Brazil.
  • Stamford TCM; UFPE - Universidade Federal de Perna mbuco, Recife, PE, Brazil.
  • Rosenblatt A; FOP - Faculdade de Odontologia de Pernambuco, UPE - Universidade de Pernambuco, Recife, PE, Brazil.
Braz Dent J ; 28(4): 417-422, 2017.
Article em En | MEDLINE | ID: mdl-29160391
The purpose of this study was to evaluate the antimicrobial properties of a new formulation containing silver nanoparticles, named Nano Silver Fluoride (NSF), to inhibit Streptococcus mutans biofilm formation on children's dental enamel. The variations in dental biofilm pH and in the Simplified-Oral-Hygiene-Index (OHI-S) also were evaluated after the treatment with NSF. This was a randomized, double-blind, crossover and prospective pilot clinical trial study in which 12 schoolchildren, aged between 7-8 years, had their dental enamel treated with two solutions: S1 - Nano Silver Fluoride and S2 - negative control (saline solution), in different experimental moments. The dental biofilm adhered to enamel treated with NSF had lower values of S. mutans viability (absorbance) and colony forming units (CFU) than the S0 (baseline) and S2. There was a statistically significant difference between the OHI-S mean values of S0 and S1. There were no differences between the biofilm pH (both before and after the use of the test substances) and among the different groups. These properties suggest that NSF has bactericidal effect against S. mutans biofilm and it may be used for clinical control and prevention of dental biofilm formation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Streptococcus mutans / Biofilmes / Nanopartículas Metálicas Tipo de estudo: Clinical_trials / Observational_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prata / Streptococcus mutans / Biofilmes / Nanopartículas Metálicas Tipo de estudo: Clinical_trials / Observational_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Braz Dent J Assunto da revista: ODONTOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil