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Antineoplastic Effects of NF-κB Inhibition by DHMEQ (Dehydroxymethylepoxyquinomicin) Alone and in Co-treatment with Radio-and Chemotherapy in Medulloblastoma Cell Lines.
Ramos, Priscila M M; Pezuk, Julia A; Castro-Gamero, Angel M; Oliveira, Harley F; Scrideli, Carlos A; Umezawa, Kazuo; Tone, Luiz G.
Afiliação
  • Ramos PMM; Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
  • Pezuk JA; Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
  • Castro-Gamero AM; Universidade Anhaguera de Sao Paulo, UNIAN-SP, Brazil.
  • Oliveira HF; Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
  • Scrideli CA; Institute of Natural Science, Federal University of Alfenas, Brazil.
  • Umezawa K; Department of Clinical Medical, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
  • Tone LG; Department of Pediatric, Ribeirao Preto Medical School, University of Sao Paulo, Brazil.
Anticancer Agents Med Chem ; 18(4): 541-549, 2018.
Article em En | MEDLINE | ID: mdl-29141555
BACKGROUND: NF-κB is a transcription factor involved in the transcriptional regulation of a large number of genes related to tumorigenesis in several cancer cell types, and its inhibition has been related to anticancer effect. DHMEQ (Dehydroxymethylepoxyquinomicin) is a compound that blocks the translocation of NF-κB from the cytoplasm to the nucleus, thus inhibiting its activity as a transcriptional activator. Several studies have shown the antineoplastic effects of DHMEQ in numerous tumor types, however, there are no surveys that tested their effects in MB. OBJECTIVES: The aim of the present study was to evaluate the effects of DHMEQ as NF-κB inhibitor in pediatric MB cell lines. METHOD: We used the UW402, UW473 and ONS-76 medulloblastoma (MB) cell lines to verify the effect of DHMEQ on proliferation, clonogenic capacity, apoptosis, cell invasion and migration, and evaluated the effect of the combination with other drugs and the potential as a radiosensitizator. RESULTS: A significant decrease in the cell growth, a strong inhibition of the clonogenic capacity, migration and cell invasion was observed after NF-κB inhibition in the three MB cell lines. Conversely, increased level of apoptosis rates were demonstrated. Additionally, treatments with DHMEQ combined with other chemotherapeutic agents were synergic in most points, and a strong radiosensitization by this compound was observed in the three MB cell lines. CONCLUSION: DHMEQ has potential antitumor effect on MB cells, and it may be considered a new therapeutic agent to improve treatment approaches in MB.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzamidas / NF-kappa B / Cicloexanonas / Meduloblastoma / Antineoplásicos Limite: Humans Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzamidas / NF-kappa B / Cicloexanonas / Meduloblastoma / Antineoplásicos Limite: Humans Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda