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Inhibitory effect of biofilm-forming Lactobacillus kunkeei strains against virulent Pseudomonas aeruginosa in vitro and in honeycomb moth (Galleria mellonella) infection model.
Berríos, P; Fuentes, J A; Salas, D; Carreño, A; Aldea, P; Fernández, F; Trombert, A N.
Afiliação
  • Berríos P; 1 Escuela de Biotecnología, Facultad de Ciencias, Universidad Mayor, Camino La Pirámide 5750, Huechuraba, Santiago 8580745, Chile.
  • Fuentes JA; 2 Laboratorio de Genética y Patogénesis Bacteriana, Facultad de Ciencias Biológicas, Universidad Andrés Bello, Av. República 217, Santiago 8370146, Chile.
  • Salas D; 3 Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Camino La Pirámide 5750, Huechuraba, Santiago 8580745, Chile.
  • Carreño A; 4 Center of Applied Nanosciences (CANS), Universidad Andres Bello, Ave. República 275, Santiago 8370146, Chile.
  • Aldea P; 5 Núcleo Milenio de Ingeniería Molecular para Catálisis y Biosensores (MECB), ICM, Av. República 275, Santiago 8370146, Chile.
  • Fernández F; 6 CEAPI Mayor, Universidad Mayor, Camino La Pirámide 5750, Huechuraba, Santiago 8580745, Chile.
  • Trombert AN; 3 Centro de Genómica y Bioinformática, Facultad de Ciencias, Universidad Mayor, Camino La Pirámide 5750, Huechuraba, Santiago 8580745, Chile.
Benef Microbes ; 9(2): 257-268, 2018 Feb 27.
Article em En | MEDLINE | ID: mdl-29124967
Biofilms correspond to complex communities of microorganisms embedded in an extracellular polymeric matrix. Biofilm lifestyle predominates in Pseudomonas aeruginosa, an opportunistic Gram negative pathogen responsible for a wide spectrum of infections in humans, plants and animals. In this context, anti-biofilm can be considered a key strategy to control P. aeruginosa infections, thereby more research in the field is required. On the other hand, Lactobacillus species have been described as beneficial due to their anti-biofilm properties and their consequent effect against a wide spectrum of pathogens. In fact, biofilm-forming Lactobacilli seem to be more efficient than their planktonic counterpart to antagonise pathogenic bacteria. In this work, we demonstrated that Lactobacillus kunkeei, a novel Lactobacillus species isolated from honeybee guts, can form biofilms in vitro. In addition, the L. kunkeei biofilm can, in turn, inhibit the formation of P. aeruginosa biofilms. Finally, we found that L. kunkeei strains attenuate infection of P. aeruginosa in the Galleria mellonella model, presumably by affecting P. aeruginosa biofilm formation and/or their stability. Since L. kunkeei presents characteristics of a probiotic, this work provides evidence arguing that the use of this Lactobacillus species in both animals (including insects) and humans could contribute to impair P. aeruginosa biofilm formation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Biofilmes / Probióticos / Lactobacillus / Mariposas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Benef Microbes Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Biofilmes / Probióticos / Lactobacillus / Mariposas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Benef Microbes Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Holanda