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Parameters Estimation in Phase-Space Landscape Reconstruction of Cell Fate: A Systems Biology Approach.
Montero, Sheyla; Martin, Reynaldo; Mansilla, Ricardo; Cocho, Germinal; Nieto-Villar, José Manuel.
Afiliação
  • Montero S; Department of Basics Science, University of Medical Science of Havana, Havana, 10400, Cuba.
  • Martin R; Department of Chemical-Physics, A. Alzola Group of Thermodynamics of Complex Systems M.V. Lomonosov Chemistry Chair, Faculty of Chemistry, University of Havana, Havana, 10400, Cuba.
  • Mansilla R; Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades, UNAM, México, Mexico.
  • Cocho G; Instituto de Física de la UNAM, México, Mexico.
  • Nieto-Villar JM; Department of Chemical-Physics, A. Alzola Group of Thermodynamics of Complex Systems M.V. Lomonosov Chemistry Chair, Faculty of Chemistry, University of Havana, Havana, 10400, Cuba. nieto@fq.uh.cu.
Methods Mol Biol ; 1702: 125-170, 2018.
Article em En | MEDLINE | ID: mdl-29119505
The thermodynamical formalism of irreversible processes offers a theoretical framework appropriate to explain the complexity observed at the macroscopic level of dynamic systems. In this context, together with the theory of complex systems and systems biology, the thermodynamical formalism establishes an appropriate conceptual framework to address the study of biological systems, in particular cancer.The Chapter is organized as follows: In Subheading 1, an integrative view of these disciplines is offered, for the characterization of the emergence and evolution of cancer, seen as a self-organized dynamic system far from the thermodynamic equilibrium. Development of a thermodynamic framework, based on the entropy production rate, is presented in Subheading 2. Subheading 3 is dedicated to all tumor growth, as seen through a "phase transitions" far from equilibrium. Subheading 4 is devoted to complexity of cancer glycolysis. Finally, some concluding remarks are presented in Subheading 5.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenômenos Fisiológicos Celulares / Biologia de Sistemas / Modelos Biológicos / Neoplasias Limite: Animals / Humans Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenômenos Fisiológicos Celulares / Biologia de Sistemas / Modelos Biológicos / Neoplasias Limite: Animals / Humans Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Cuba País de publicação: Estados Unidos