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Trait-specific long-term consequences of genomic selection in beef cattle.
de Rezende Neves, Haroldo Henrique; Carvalheiro, Roberto; de Queiroz, Sandra Aidar.
Afiliação
  • de Rezende Neves HH; Departamento de Zootecnia, School of Agricultural and Veterinarian Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Prof. Paulo Donato Castellane s/n, Jaboticabal, SP, 14884-900, Brazil.
  • Carvalheiro R; GenSys Consultores Associados S/S Ltda., Rua Guilherme Alves, 170. Cj 304, Porto Alegre, RS, 90680-000, Brazil.
  • de Queiroz SA; Departamento de Zootecnia, School of Agricultural and Veterinarian Sciences (FCAV), São Paulo State University (UNESP), Via de Acesso Prof. Paulo Donato Castellane s/n, Jaboticabal, SP, 14884-900, Brazil.
Genetica ; 146(1): 85-99, 2018 Feb.
Article em En | MEDLINE | ID: mdl-29119314
Simulation studies allow addressing consequences of selection schemes, helping to identify effective strategies to enable genetic gain and maintain genetic diversity. The aim of this study was to evaluate the long-term impact of genomic selection (GS) in genetic progress and genetic diversity of beef cattle. Forward-in-time simulation generated a population with pattern of linkage disequilibrium close to that previously reported for real beef cattle populations. Different scenarios of GS and traditional pedigree-based BLUP (PBLUP) selection were simulated for 15 generations, mimicking selection for female reproduction and meat quality. For GS scenarios, an alternative selection criterion was simulated (wGBLUP), intended to enhance long-term gains by attributing more weight to favorable alleles with low frequency. GS allowed genetic progress up to 40% greater than PBLUP, for female reproduction and meat quality. The alternative criterion wGBLUP did not increase long-term response, although allowed reducing inbreeding rates and loss of favorable alleles. The results suggest that GS outperforms PBLUP when the selected trait is under less polygenic background and that attributing more weight to low-frequency favorable alleles can reduce inbreeding rates and loss of favorable alleles in GS.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Bovinos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genetica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Bovinos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Genetica Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda