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Prevalence of cocaine and derivatives in blood and urine samples of trauma patients and correlation with injury severity: a prospective observational study.
Oliveira, K D; Fraga, G P; Baracat, E C E; Morcillo, A M; Lanaro, R; Costa, J L; Capitani, E M; Bucaretchi, F; Ferreira Filho, A I; Gimenes, V C; de Azevedo, R C S.
Afiliação
  • Oliveira KD; Division of Psychiatry, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil. karina.dinizoliveira@gmail.com.
  • Fraga GP; Division of Trauma Surgery, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Baracat ECE; Division of Pediatry, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Morcillo AM; Division of Pediatry, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Lanaro R; Faculty of Medical Sciences, Poison Control Center, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Costa JL; Faculty of Pharmaceutical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Capitani EM; Division of Medical Clinic, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Bucaretchi F; Division of Pediatry, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Ferreira Filho AI; School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • Gimenes VC; School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
  • de Azevedo RCS; Division of Psychiatry, School of Medical Sciences, University of Campinas, Rua Tessalia Vieira de Camargo, 126, Campinas, São Paulo, SP, Brazil.
Eur J Trauma Emerg Surg ; 45(1): 159-165, 2019 Feb.
Article em En | MEDLINE | ID: mdl-29116350
PURPOSE: The abuse of cocaine and its derivatives presents a likely risk factor for injury. Trauma incurred by cocaine and derivative abusers may be more severe than that incurred by non-users. OBJECTIVES: To ascertain the presence of cocaine and its derivatives in trauma patients and to correlate RTS (Revised Trauma Score) and ISS (Injury Severity Score) with the presence of cocaine and its derivatives in blood and urine samples. METHODS: All trauma victims treated in an emergency unit between November 11, 2012 and September 15, 2013 were included in the study. Blood and urine samples were collected on admission to hospital. RTS and ISS scores were then compared with the presence or absence of cocaine and its derivatives in the samples. The associations between RTS < 7.84 and ISS > 16 and the independent variables were evaluated by the gross odds ratio values, determined by univariate logistic regression. Multivariate analysis was performed using multivariate logistic regression. RESULTS: Of 453 patients (83.7% male) included in the study, 28.6% presented ISS > 16 and 33.6% presented RTS < 7.84. A total of 435 samples were collected, and 86 (19.8%) provided positive samples for cocaine, 48 (11%) for crack and 69 (15.9%) for cocaethylene. Compared to other patients, drug users showed a greater probability of RTS < 7.84 (2.18 times greater) and a greater probability of ISS > 16 (1.76 times greater). CONCLUSION: For the trauma patients included in our study, the use of cocaine and its derivatives was shown to be associated with more severe traumas, as demonstrated by their RTS and ISS scores.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferimentos e Lesões / Detecção do Abuso de Substâncias / Cocaína Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Eur J Trauma Emerg Surg Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferimentos e Lesões / Detecção do Abuso de Substâncias / Cocaína Tipo de estudo: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Revista: Eur J Trauma Emerg Surg Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Alemanha