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ENPP1 and ESR1 genotypes associated with subclassifications of craniofacial asymmetry and severity of temporomandibular disorders.
Chung, Kay; Richards, Tabitha; Nicot, Romain; Vieira, Alexandre R; Cruz, Christiane V; Raoul, Gwénaël; Ferri, Joel; Sciote, James J.
Afiliação
  • Chung K; Department of Orthodontics, Temple University, Philadelphia, Pa.
  • Richards T; Department of Orthodontics, Temple University, Philadelphia, Pa.
  • Nicot R; Department of Oral and Maxillofacial Surgery, Roger Salengro Hospital, Université Lille Nord de France, Lille, France.
  • Vieira AR; Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pa.
  • Cruz CV; Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Raoul G; Department of Oral and Maxillofacial Surgery, Roger Salengro Hospital, Université Lille Nord de France, Lille, France.
  • Ferri J; Department of Oral and Maxillofacial Surgery, Roger Salengro Hospital, Université Lille Nord de France, Lille, France.
  • Sciote JJ; Department of Orthodontics, Temple University, Philadelphia, Pa. Electronic address: jjs6@temple.edu.
Am J Orthod Dentofacial Orthop ; 152(5): 631-645, 2017 Nov.
Article em En | MEDLINE | ID: mdl-29103441
INTRODUCTION: We investigated whether ACTN3, ENPP1, ESR1, PITX1, and PITX2 genes which contribute to sagittal and vertical malocclusions also contribute to facial asymmetries and temporomandibular disorders (TMD) before and after orthodontic and orthognathic surgery treatment. METHODS: One hundred seventy-four patients with a dentofacial deformity were diagnosed as symmetric or subdivided into 4 asymmetric groups according to posteroanterior cephalometric measurements. TMD examination diagnosis and jaw pain and function (JPF) questionnaires assessed the presence and severity of TMD. RESULTS: Fifty-two percent of the patients were symmetric, and 48% were asymmetric. The asymmetry classification demonstrated significant cephalometric differences between the symmetric and asymmetric groups, and across the 4 asymmetric subtypes: group 1, mandibular body asymmetry; group 2, ramus asymmetry; group 3, atypical asymmetry; and group 4, C-shaped asymmetry. ENPP1 SNP-rs6569759 was associated with group 1 (P = 0.004), and rs858339 was associated with group 3 (P = 0.002). ESR1 SNP-rs164321 was associated with group 4 (P = 0.019). These results were confirmed by principal component analysis that showed 3 principal components explaining almost 80% of the variations in the studied groups. Principal components 1 and 2 were associated with ESR1 SNP-rs3020318 (P <0.05). Diagnoses of disc displacement with reduction, masticatory muscle myalgia, and arthralgia were highly prevalent in the asymmetry groups, and all had strong statistical associations with ENPP1 rs858339. The average JPF scores for asymmetric subjects before surgery (JPF, 7) were significantly higher than for symmetric subjects (JPF, 2). Patients in group 3 had the highest preoperative JPF scores, and groups 2 and 3 were most likely to be cured of TMD 1 year after treatment. CONCLUSIONS: Posteroanterior cephalometrics can classify asymmetry into distinct groups and identify the probability of TMD and genotype associations. Orthodontic and orthognathic treatments of facial asymmetry are effective at eliminating TMD in most patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirofosfatases / Transtornos da Articulação Temporomandibular / Diester Fosfórico Hidrolases / Receptor alfa de Estrogênio / Assimetria Facial / Deformidades Dentofaciais Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Am J Orthod Dentofacial Orthop Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirofosfatases / Transtornos da Articulação Temporomandibular / Diester Fosfórico Hidrolases / Receptor alfa de Estrogênio / Assimetria Facial / Deformidades Dentofaciais Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Am J Orthod Dentofacial Orthop Assunto da revista: ODONTOLOGIA / ORTODONTIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Estados Unidos