Your browser doesn't support javascript.
loading
Outbreak of chikungunya virus in a vulnerable population of Sergipe, Brazil-A molecular and serological survey.
Cunha, Marielton Dos Passos; Santos, Cliomar Alves Dos; Neto, Daniel Ferreira de Lima; Schanoski, Alessandra Soares; Pour, Shahab Zaki; Passos, Saulo Duarte; Souza, Mércia Simone Feitosa de; Costa, Danuza Duarte; Zanotto, Paolo Marinho de Andrade.
Afiliação
  • Cunha MDP; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Santos CAD; Health Foundation Parreiras Horta (FSPH), Central Laboratory of Public Health (LACEN/SE), State Secretary for Health, Sergipe, Brazil.
  • Neto DFL; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Schanoski AS; Bacteriology Laboratory II, Butantan Institute, São Paulo, Brazil.
  • Pour SZ; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.
  • Passos SD; Department of Pediatrics, Jundiaí Medical Faculty, São Paulo, Brazil.
  • Souza MSF; Coordination of the Nucleus of Communicable Diseases, State Secretary for Health, Sergipe, Brazil.
  • Costa DD; Health Foundation Parreiras Horta (FSPH), Central Laboratory of Public Health (LACEN/SE), State Secretary for Health, Sergipe, Brazil.
  • Zanotto PMA; Laboratory of Molecular Evolution and Bioinformatics, Department of Microbiology, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil. Electronic address: pzanotto@usp.br.
J Clin Virol ; 97: 44-49, 2017 12.
Article em En | MEDLINE | ID: mdl-29100064
BACKGROUND: Chikungunya virus (CHIKV) is a re-emerging arbovirus that is causing outbreaks in several countries of the Americas. The virus was introduced in Brazil in 2014, and since then, several Brazilian states have notified autochthonous cases. OBJECTIVES: Provide additional evidence on a CHIKV outbreak and an outline of the laboratory and clinical profile of symptomatic patients in Sergipe, Brazil. STUDY DESIGN: In February 2016, we collected 142 serum samples from symptomatic patients for arboviruses in Sergipe, Brazil. All samples were submitted to qRT-PCR for the emerging arboviruses circulating in Brazil - ZIKV, CHIKV, and DENV - and later submitted to the immunoenzymatic assay. RNA positive samples were randomly selected and sequenced for characterization of the genotype involved in the outbreak. RESULTS: Our study had 75.35% (107/142) positivity for CHIKV infection, with all age groups and genera being equally infected. The virus was identified in 11 of the 13 cities studied in that state, including the ECSA genotype. Importantly, fever was the only statistically significant symptoms for CHIKV infection (p<0.05), while asthenia was significantly associated with symptomatic patients that were CHIKV-negative (p<0.05). CONCLUSIONS: Our findings support the importance of fever as a clinical marker and contribute to molecular and serological surveillance data, which may help in the understanding of CHIKV circulation, emergence and clinical description.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Vigilância da População / Surtos de Doenças / Populações Vulneráveis / Febre de Chikungunya Tipo de estudo: Etiology_studies / Prognostic_studies / Screening_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Chikungunya / Vigilância da População / Surtos de Doenças / Populações Vulneráveis / Febre de Chikungunya Tipo de estudo: Etiology_studies / Prognostic_studies / Screening_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn País/Região como assunto: America do sul / Brasil Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda