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Parvovirus B19 in HIV+ adult patients with different CD4+ lymphocyte counts.
Pedranti, Mauro Sebastian; Rodriguez-Lombardi, Gonzalo; Bracciaforte, Romina; Romano, Natalia; Lujan, Pablo; Ricchi, Brenda; Mautino, Jorge; Adamo, Maria Pilar.
Afiliação
  • Pedranti MS; Institutode Virología 'Dr J. M. Vanella', Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Rodriguez-Lombardi G; Fundaciónpara el Progreso de la Medicina, Córdoba, Argentina.
  • Bracciaforte R; Laboratoriode Hemoderivados, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Romano N; Institutode Virología 'Dr J. M. Vanella', Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Lujan P; Hospital Infantil Municipal, Córdoba, Argentina.
  • Ricchi B; Hospital Privado, Centro Médico de Córdoba, Córdoba, Argentina.
  • Mautino J; Hospital Privado, Centro Médico de Córdoba, Córdoba, Argentina.
  • Adamo MP; Fundaciónpara el Progreso de la Medicina, Córdoba, Argentina.
J Med Microbiol ; 66(12): 1715-1721, 2017 Dec.
Article em En | MEDLINE | ID: mdl-29095139
PURPOSE: Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia. METHODOLOGY: We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 healthy individuals. HIV load, CD4+ counts and haemoglobin level were also determined in the patients. RESULTS: No individual in the control group had detectable IgM, 41/52 (78.8 %) had IgG and 5/52 (9.6 %) had B19V DNA. Among HIV+ patients, we found 5/98 (5.1 %) IgM+, 66/98 (67.3 %) IgG+ and 15/98 (15.3 %) had B19V DNA (no significant differences between the two groups compared). Considering the CD4+ cell range in HIV patients, 37 had <200 CD4+ cells ml-1, 31 had 200-500, and 30 had >500. Anti-B19V IgG prevalence in patients with >500 CD4+ cells ml-1 was significantly higher than in the rest (P=0.004) and compared to the control (P=0.046). B19V DNA concentration was always <103 IU ml-1, including 5 healthy individuals and 15 HIV+ patients. There was no significant association between B19V IgM or DNA and anemia nor between B19V DNA and HIV load. CONCLUSIONS: The results indicate that B19V is not a high-risk factor for anemia in adult HIV+ patients under HAART treatment. Further studies will contribute to elucidate the mechanisms and significance of B19V DNA prevalence/persistence in adults, independently of the CD4+ cell status.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Parvovirus B19 Humano / Infecções por Parvoviridae / Contagem de Linfócito CD4 Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Med Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Parvovirus B19 Humano / Infecções por Parvoviridae / Contagem de Linfócito CD4 Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Med Microbiol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Reino Unido