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First case of New Delhi metallo-ß-lactamase in Klebsiella pneumoniae from Ecuador: An update for South America.
Romero-Alvarez, Daniel; Reyes, Jorge; Quezada, Viviana; Satán, Carolina; Cevallos, Nelson; Barrera, Sofía; Trueba, Gabriel; Escobar, Luis E; Villacís, José E.
Afiliação
  • Romero-Alvarez D; Hospital General Enrique Garcés, Quito, Ecuador; Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, KS, USA. Electronic address: da.romero@ku.edu.
  • Reyes J; Instituto Nacional de Investigación en Salud Pública (INSPI) "Dr. Leopoldo Izquieta Pérez," Quito, Ecuador; Universidad San Francisco de Quito, Quito, Ecuador; Universidad Central del Ecuador, Quito, Ecuador; Hospital Carlos Andrade Marín, Quito, Ecuador.
  • Quezada V; Hospital General Enrique Garcés, Quito, Ecuador.
  • Satán C; Instituto Nacional de Investigación en Salud Pública (INSPI) "Dr. Leopoldo Izquieta Pérez," Quito, Ecuador.
  • Cevallos N; Hospital General Enrique Garcés, Quito, Ecuador.
  • Barrera S; Universidad San Francisco de Quito, Quito, Ecuador.
  • Trueba G; Universidad San Francisco de Quito, Quito, Ecuador.
  • Escobar LE; Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, VA, USA.
  • Villacís JE; Instituto Nacional de Investigación en Salud Pública (INSPI) "Dr. Leopoldo Izquieta Pérez," Quito, Ecuador; Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Int J Infect Dis ; 65: 119-121, 2017 Dec.
Article em En | MEDLINE | ID: mdl-29081367
OBJECTIVES: To describe a clinical case of Klebsiella pneumoniae harboring a New Delhi metallo-ß-lactamase (NDM) plasmid in Ecuador and to present a map of reports of NDM isolates in South America. METHODS: The modified Hodge test, carbapenem inactivation method, imipenem-EDTA disk method (synergy), and Rapidec Carba NP test were used to identify antibiotic resistance mechanisms. The presence of resistance genes was explored with a conjugation assay, and molecular confirmation of NDM was performed by PCR and DNA sequencing. Plasmid characterization was conducted by PCR-based replicon typing. A literature review was performed in Google Scholar and PubMed to identify reports from South America. RESULTS: An HIV-infected patient, who had never traveled abroad, developed a bloodstream infection caused by K. pneumoniae ST147 harboring the NDM-1 resistance gene in a plasmid from the IncA/C group. Local circulation of NDM has also been described in other South American countries, in particular in Colombia and Brazil, although published scientific records were not found for other countries. CONCLUSIONS: This report presents the first evidence of autochthonous circulation of the NDM-1 resistance gene harbored by an IncA/C plasmid isolated from a K. pneumoniae ST147 in Ecuador. Efforts should be implemented to monitor and characterize the spatial and temporal distribution of NDM in Ecuador and other countries of South America.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Infecções por Klebsiella / Fatores R / Klebsiella pneumoniae Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article País de publicação: Canadá
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Infecções por Klebsiella / Fatores R / Klebsiella pneumoniae Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male País/Região como assunto: America do sul / Ecuador Idioma: En Revista: Int J Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2017 Tipo de documento: Article País de publicação: Canadá