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Endogenous antibody responses to mucin 1 in a large multiethnic cohort of patients with breast cancer and healthy controls: Role of immunoglobulin and Fcγ receptor genes.
Pandey, Janardan P; Namboodiri, Aryan M; Wolf, Bethany; Iwasaki, Motoki; Kasuga, Yoshio; Hamada, Gerson S; Tsugane, Shoichiro.
Afiliação
  • Pandey JP; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States. Electronic address: pandeyj@musc.edu.
  • Namboodiri AM; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, United States.
  • Wolf B; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, United States.
  • Iwasaki M; Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
  • Kasuga Y; Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan.
  • Hamada GS; Nikkei Disease Prevention Center, São Paulo, Brazil.
  • Tsugane S; Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Immunobiology ; 223(2): 178-182, 2018 02.
Article em En | MEDLINE | ID: mdl-29074302
High levels of naturally occurring IgG antibodies to mucin 1 (MUC1), a membrane-bound glycoprotein that is overexpressed in patients with breast cancer, are associated with good prognosis. This suggests that endogenous anti-MUC1 antibodies have a protective effect and, through antibody-mediated host immunosurveillance mechanisms, might contribute to a cancer-free state. To test this possibility, we characterized a large number of multiethnic patients with breast cancer and matched controls for IgG antibodies to MUC1. We also aimed to determine whether the magnitude of anti-MUC1 antibody responsiveness was associated with particular immunoglobulin GM (γ marker), KM (κ marker), and Fcγ receptors (FcγR) genotypes. After adjusting for the confounding variables in a multivariate analysis, we found no significant difference in the levels of anti-MUC1 IgG antibodies between patients and cancer-free controls. However, in patients and controls, particular GM, KM, and FcγR genotypes-individually or epistatically-were significantly associated with the levels of anti-MUC1 IgG antibodies in a racially restricted manner. These findings, if confirmed in an independent investigation, could help identify individuals most likely to benefit from a MUC1-based therapeutic or prophylactic vaccine for MUC1-overexpressing malignancies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Imunoglobulinas / Etnicidade / Receptores de IgG / Mucina-1 / Grupos Raciais / Genótipo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: America do sul / Asia / Brasil Idioma: En Revista: Immunobiology Ano de publicação: 2018 Tipo de documento: Article País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Imunoglobulinas / Etnicidade / Receptores de IgG / Mucina-1 / Grupos Raciais / Genótipo Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans País/Região como assunto: America do sul / Asia / Brasil Idioma: En Revista: Immunobiology Ano de publicação: 2018 Tipo de documento: Article País de publicação: Holanda