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Photodynamic Therapy Associated with a Blue Dye Papain-Based Gel and Evaluation of Its Degradation of Type I Collagen Fibers.
Botta, Sergio Brossi; Ana, Patricia Aparecida; Gonçalves, Marcela Leticia Leal; Fernandes, Kristianne Porta Santos; Mesquita-Ferrari, Raquel Agnelli; de Araújo Prates, Renato; Brugnera, Aldo; Bussadori, Sandra Kalil.
Afiliação
  • Botta SB; 1 Postgraduate Program, Biophotonics Applied to Health Sciences, Nove de Julho University , São Paulo, São Paulo, Brazil .
  • Ana PA; 2 Engineering Center, Modeling and Applied Social Sciences, Federal University of ABC , Sao Bernardo do Campo, São Paulo, Brazil .
  • Gonçalves MLL; 1 Postgraduate Program, Biophotonics Applied to Health Sciences, Nove de Julho University , São Paulo, São Paulo, Brazil .
  • Fernandes KPS; 1 Postgraduate Program, Biophotonics Applied to Health Sciences, Nove de Julho University , São Paulo, São Paulo, Brazil .
  • Mesquita-Ferrari RA; 1 Postgraduate Program, Biophotonics Applied to Health Sciences, Nove de Julho University , São Paulo, São Paulo, Brazil .
  • de Araújo Prates R; 1 Postgraduate Program, Biophotonics Applied to Health Sciences, Nove de Julho University , São Paulo, São Paulo, Brazil .
  • Brugnera A; 3 National Institute of Science and Technology , INCT "Basic Optics Applied to Life Sciences," IFSC, USP, São Carlos, São Paulo, Brazil .
  • Bussadori SK; 1 Postgraduate Program, Biophotonics Applied to Health Sciences, Nove de Julho University , São Paulo, São Paulo, Brazil .
Photomed Laser Surg ; 36(2): 100-104, 2018 Feb.
Article em En | MEDLINE | ID: mdl-29023186
OBJECTIVE: The aim of this in vitro study was to evaluate the degradation of type I collagen fibers after treatment with a papain-based gel associated with a blue dye (PapaMBlue™) for use in antimicrobial photodynamic therapy. MATERIALS AND METHODS: For such, 60 bioabsorbable membrane sponge discs were used. Group 1 was the negative control group. In groups 2, 3, and 4, the papain-based gel PapaMBlue gel was applied all over the samples for 4 min and irradiated using red laser (660 ± 10 nm) with 15, 30, and 40 J/cm2, respectively. In group 5, the papain-based gel was applied all over the samples for 4 min. In group 6, the photosensitizing dye was applied all over the samples for 4 min. The compositional analysis of the samples was performed using ATR-FTIR (attenuated total reflectance-Fourier transformed infrared spectroscopy). The data were statistically analyzed using ANOVA and Tukey's test (p < 0.05). RESULTS: Neither classic Papacarie™ nor the modified product with a photosensitizing agent (PapaMBlue) promoted collagen degradation. CONCLUSIONS: The irradiation of methylene blue added to papain gel with red light did not alter the chemical structure of type I collagen.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Fármacos Fotossensibilizantes / Colágeno Tipo I / Azul de Metileno Tipo de estudo: Evaluation_studies / Observational_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Photomed Laser Surg Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Fármacos Fotossensibilizantes / Colágeno Tipo I / Azul de Metileno Tipo de estudo: Evaluation_studies / Observational_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Photomed Laser Surg Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos