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Biotransformation of (-)-cubebin by Aspergillus spp. into (-)-hinokinin and (-)-parabenzlactone, and their evaluation against oral pathogenic bacteria.
Arruda, Caroline; Eugênio, Daniele de Souza; Moreira, Monique Rodrigues; Símaro, Guilherme Venâncio; Bastos, Jairo Kenupp; Martins, Carlos Henrique Gomes; Silva, Márcio Luís Andrade; Veneziani, Rodrigo Cássio Sola; Vieira, Paula Bruzadelle; Ambrósio, Sérgio R.
Afiliação
  • Arruda C; a School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • Eugênio DS; b Biotechnology Department , University of Ribeirão Preto , Ribeirão Preto , Brazil.
  • Moreira MR; c Nucleus of Research in Sciences and Technology , University of Franca , Franca , Brazil.
  • Símaro GV; a School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • Bastos JK; a School of Pharmaceutical Sciences of Ribeirão Preto , University of São Paulo , Ribeirão Preto , Brazil.
  • Martins CHG; c Nucleus of Research in Sciences and Technology , University of Franca , Franca , Brazil.
  • Silva MLA; c Nucleus of Research in Sciences and Technology , University of Franca , Franca , Brazil.
  • Veneziani RCS; c Nucleus of Research in Sciences and Technology , University of Franca , Franca , Brazil.
  • Vieira PB; b Biotechnology Department , University of Ribeirão Preto , Ribeirão Preto , Brazil.
  • Ambrósio SR; c Nucleus of Research in Sciences and Technology , University of Franca , Franca , Brazil.
Nat Prod Res ; 32(23): 2803-2816, 2018 Dec.
Article em En | MEDLINE | ID: mdl-28982254
The biotransformation of the lignan (-)-cubebin by filamentous fungi Aspergillus terreus and Aspergillus niger is an efficient bioprocess for obtaining (-)-hinokinin and (-)-parabenzlactone. The relevance of getting (-)-hinokinin is due to its promising effect against oral pathogens, especially S. sanguinis (both MIC and MBC 12.5 µg/mL), and other previous reported effects against Chagas disease and as anti-inflammatory. The advantage of using fungal transformation is the use of non-toxic and/or non-pollutant reagents and/or solvents in comparison with semi-synthesis. Microbial transformation of (-)-cubebin is also important to evaluate its human metabolism, since Aspergillus species are capable of mimicking P450 reactions, providing possible products of the metabolism, which is important in the assessment of its efficacy and safety. Furthermore, the present study describes a reliable RP-HPLC method to perform quantification of (-)-hinokinin in fungal extracts. It is simple, fast, selective, linear, precise, accurate and robust according to validation guidelines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus / Bactérias / Compostos de Benzil / 4-Butirolactona / Biotransformação / Lignanas / Benzodioxóis / Lactonas Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aspergillus / Bactérias / Compostos de Benzil / 4-Butirolactona / Biotransformação / Lignanas / Benzodioxóis / Lactonas Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido