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Early sex differences in central arterial wave reflection are mediated by different timing of forward and reflected pressure waves.
Zaniqueli, Divanei; Baldo, Marcelo Perim; Sartório, Carmem Luiza; de Sá Cunha, Roberto; de Oliveira Alvim, Rafael; Mill, José Geraldo.
Afiliação
  • Zaniqueli D; Department of Physiological Sciences, Cardiovascular Investigation Clinic, Federal University of Espírito Santo, Vitória, Brazil.
  • Baldo MP; Department of Pathophysiology, Montes Claros State University, Montes Claros, Brazil.
  • Sartório CL; Department of Physiological Sciences, Cardiovascular Investigation Clinic, Federal University of Espírito Santo, Vitória, Brazil.
  • de Sá Cunha R; Department of Physiological Sciences, Cardiovascular Investigation Clinic, Federal University of Espírito Santo, Vitória, Brazil.
  • de Oliveira Alvim R; Department of Physiological Sciences, Cardiovascular Investigation Clinic, Federal University of Espírito Santo, Vitória, Brazil.
  • Mill JG; Department of Physiological Sciences, Cardiovascular Investigation Clinic, Federal University of Espírito Santo, Vitória, Brazil.
Clin Exp Pharmacol Physiol ; 45(2): 166-173, 2018 02.
Article em En | MEDLINE | ID: mdl-28972675
Non-invasive assessment of central arterial pulse wave augmentation has been proved to be useful in predicting cardiovascular adverse events. Previous studies have shown that pre-pubescent girls had greater central augmentation pressure compared with height-matched boys. This study sought to investigate which factors contribute to the body height-independent sexual differences in central arterial wave reflection observed in childhood. This cross-sectional study involved 819 children and adolescents (6-18 years of age) of both sexes. Phenotypes of central haemodynamic were obtained by radial applanation tonometry. Heart rate corrected augmentation index (Aix@75) was greater in girls compared with boys (2.9 ± 10.7 vs -1.7 ± 12.9%, P < .001) as well as the central augmented pressure (cAP; 1.3 ± 3.3 vs 0.1 ± 3.8 mm Hg, P < .001), even adjusting for age, heart rate and body height. Left ventricular ejection duration (ED) was longer (320 ± 26 vs 314 ± 24 ms, P = .004) and time to inflection point (Tr) was shorter in girls (139 ± 14 vs 141 ± 21 ms, P = .014). The reduction of Aix@75 with increasing body height was steeper in boys (-0.499 ± 0.030 vs -0.428 ± 0.036%/cm, P < .001) as well as the reduction of cAP with increasing body height (-0.108 ± 0.010 vs -0.066 ± 0.013 mm Hg/cm, P < .001). Body height-independent sexual differences observed in the pulse wave reflection indices from early adolescence were mediated by different timing of forward and reflected pressure waves.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise de Onda de Pulso / Hemodinâmica Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Clin Exp Pharmacol Physiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Análise de Onda de Pulso / Hemodinâmica Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Clin Exp Pharmacol Physiol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Austrália