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Alterations in expression of endometrial milk fat globule-EGF factor 8 (MFG-E8) and leukemia inhibitory factor (LIF) in patients with infertility and endometriosis.
Schmitz, Carla Regina; Oehninger, Sergio; Genro, Vanessa Krebs; Chandra, Neelima; Lattanzio, Frank; Yu, Liang; Cunha-Filho, João Sabino.
Afiliação
  • Schmitz CR; Graduate Program in Internal Medicine of the Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Oehninger S; Department of Obstetrics and Gynecology, Eastern Virginia Medical School, The Jones Institute for Reproductive Medicine, Norfolk VA, USA.
  • Genro VK; Department of Obstetrics and Gynecology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Chandra N; Department of Obstetrics and Gynecology, Eastern Virginia Medical School, The Jones Institute for Reproductive Medicine, Norfolk VA, USA.
  • Lattanzio F; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk VA, USA.
  • Yu L; Department of Obstetrics and Gynecology, Eastern Virginia Medical School, The Jones Institute for Reproductive Medicine, Norfolk VA, USA.
  • Cunha-Filho JS; Graduate Program in Internal Medicine of the Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
JBRA Assist Reprod ; 21(4): 313-320, 2017 12 01.
Article em En | MEDLINE | ID: mdl-28967712
OBJECTIVE: The aim of this study was to compare the endometrial expression of milk fat globule-EGF factor 8 (MFG-E8), its receptor integrin αvß3, and leukemia inhibitory factor (LIF) in patients with endometriosis and infertility and in healthy fertile patients during the window of implantation. METHODS: Five patients with peritoneal endometriosis and infertility (case group) and four healthy fertile patients (control group) were recruited. All patients were either diagnosed with or ruled out for endometriosis by laparoscopic surgery; the case group underwent surgery for infertility investigation and the control group for tubal ligation. Endometrial biopsies were performed in all patients during the window of implantation (LH+8 to LH+10), and then the samples were analyzed by immunochemistry for MFG-E8, integrin αvß3, and LIF. RESULTS: In patients with endometriosis and infertility, expression of MFG-E8 was significantly increased in the glandular epithelium when compared to healthy fertile patients (p<0.001). Moreover, LIF expression was lower in patients with endometriosis and infertility (p<0.05). Nevertheless, we found no difference in integrin αvß3 expression between the groups (p=0.084). CONCLUSION: This study showed for the first time that MFG-E8 expression is impaired in the endometrium of patients with endometriosis and infertility during the window of implantation. Moreover, LIF is also diminished in the endometrium of these patients as shown before.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Peritoneais / Endometriose / Endométrio / Fator Inibidor de Leucemia / Infertilidade Feminina / Proteínas do Leite / Antígenos de Superfície Tipo de estudo: Observational_studies Limite: Adult / Female / Humans Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Peritoneais / Endometriose / Endométrio / Fator Inibidor de Leucemia / Infertilidade Feminina / Proteínas do Leite / Antígenos de Superfície Tipo de estudo: Observational_studies Limite: Adult / Female / Humans Idioma: En Revista: JBRA Assist Reprod Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil