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Chemical and biological studies of ß-carotene after exposure to Cannabis sativa smoke.
do Monte, Dulciana S; Bezerra Tenório, Jonh A; Bastos, Isla V G A; de S Mendonça, Fábio; Neto, Joaquim E; da Silva, Teresinha G; Ramos, Clécio S.
Afiliação
  • do Monte DS; Department of Chemistry, Federal Rural University of Pernambuco, Recife-Pe, Brazil.
  • Bezerra Tenório JA; Department of Chemistry, Federal Rural University of Pernambuco, Recife-Pe, Brazil.
  • Bastos IVGA; Antibiotics Department, Federal University of Pernambuco, Recife-Pe, Brazil.
  • de S Mendonça F; Department of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Recife-Pe, Brazil.
  • Neto JE; Department of Morphology and Animal Physiology, Federal Rural University of Pernambuco, Recife-Pe, Brazil.
  • da Silva TG; Antibiotics Department, Federal University of Pernambuco, Recife-Pe, Brazil.
  • Ramos CS; Department of Chemistry, Federal Rural University of Pernambuco, Recife-Pe, Brazil.
Toxicol Rep ; 3: 516-522, 2016.
Article em En | MEDLINE | ID: mdl-28959575
Considering the increase in consumption of Cannabis sativa and the use of the compound ß-carotene (BC) as supplement, we investigated potential changes in the chemical and biological proprieties of BC after exposure to C. sativa smoke (CSS). Our results showed that the BC exposed to CSS underwent 98.8% degradation and suffered loss of its antiradical activity. The major degradation products identified were 3-hydroxy-2,4,4-trimethylpentyl)2-methylpropanoate and (2-ethyl-3-hydroxyhexyl)2-methylpropanoate compounds. These are found in higher levels in the exhalations of colorectal cancer patients and are similar to the toxic products associated with lipid peroxidation of polyunsaturated fatty acids. In toxicological assays using micro-crustacean Artemia salina the BC was non-toxic, while the BC degraded by CSS had a toxicity of LC50 = 397.35 µg/mL. In Wistar rats, females treated with BC degraded by CSS (BCCSS) showed whitish liver spots, alterations in liver weight and in bilirubin and alkaline phosphatase levels, and decrease in the number of leukocytes associated with atypical lymphocytosis. In male rats, there was an increase in the number of leukocytes when compared to the control group. In the histopathological analysis, the cortical region of the kidneys showed the presence of discrete amorphous eosinophilic material (cylinders) in the lumen of the proximate and distal convoluted tubules. In general, the BC in contact with CSS undergoes chemical changes and exhibits toxicity to rats and Artemia salina.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Brasil País de publicação: Irlanda