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The metabolic and neuroinflammatory changes induced by consuming a cafeteria diet are age-dependent.
Teixeira, Deborah; Cecconello, Ana Lucia; Partata, Wania Aparecida; de Fraga, Luciano Stürmer; Ribeiro, Maria Flávia Marques; Guedes, Renata Padilha.
Afiliação
  • Teixeira D; a Department of Physiology , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.
  • Cecconello AL; a Department of Physiology , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.
  • Partata WA; a Department of Physiology , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.
  • de Fraga LS; a Department of Physiology , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.
  • Ribeiro MFM; a Department of Physiology , Federal University of Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.
  • Guedes RP; b Departament of Basic Health Sciences , Federal University of Health Sciences of Porto Alegre (UFCSPA) , Porto Alegre , Brazil.
Nutr Neurosci ; 22(4): 284-294, 2019 Apr.
Article em En | MEDLINE | ID: mdl-28958196
OBJECTIVES: To compare the effects of a palatable cafeteria diet on serum parameters and neuroinflammatory markers of young and aged female Wistar rats. METHODS: Three-month-old (young) and 18-month-old (aged) female Wistar rats had access to a cafeteria diet (Caf-Young, Caf-Aged) or a standard chow diet (Std-Young, Std-Aged). RESULTS: The Caf-Young group showed a higher food consumption, weight gain, visceral fat depot, serum insulin and leptin levels, and the insulin resistance index (HOMA-IR) than the Std-Young group. The Caf-Aged group exhibited an increase in interleukin-1 levels in the cerebral cortex and hippocampus. The number of GFAP-positive cells did not differ between the groups, but there was a diet effect in the cerebral cortex and an age effect in the hippocampus. Phospho-tau expression did not differ between the groups. DISCUSSION: The 3- and 18-month-old rats responded differently to a cafeteria diet. Insulin and leptin levels are elevated in young animals fed a cafeteria diet, whereas aged animals are prone to neuroinflammation (indicated by an increase in interleukin-1ß levels). A combination of hypercaloric diet and senescence have detrimental effects on the inflammatory response in the brain, which may predispose to neurological diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Envelhecimento / Encefalite / Dieta Hiperlipídica Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Envelhecimento / Encefalite / Dieta Hiperlipídica Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Nutr Neurosci Assunto da revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido