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Effect of nanoencapsulation using PLGA on antioxidant and antimicrobial activities of guabiroba fruit phenolic extract.
Pereira, Marina C; Oliveira, Daniela A; Hill, Laura E; Zambiazi, Rui Carlos; Borges, Caroline D; Vizzotto, Marcia; Mertens-Talcott, Susanne; Talcott, Stephen; Gomes, Carmen L.
Afiliação
  • Pereira MC; Department of Food Science and Technology, Federal University of Pelotas, Faculdade de Agronomia Eliseu Maciel, Campus Capão do Leão, Pelotas, RS 96010-900, Brazil.
  • Oliveira DA; Department of Biological & Agricultural Engineering, Texas A&M University, College Station, TX 77843-2117, United States.
  • Hill LE; Department of Biological & Agricultural Engineering, Texas A&M University, College Station, TX 77843-2117, United States.
  • Zambiazi RC; Department of Food Science and Technology, Federal University of Pelotas, Faculdade de Agronomia Eliseu Maciel, Campus Capão do Leão, Pelotas, RS 96010-900, Brazil.
  • Borges CD; Department of Food Science and Technology, Federal University of Pelotas, Faculdade de Agronomia Eliseu Maciel, Campus Capão do Leão, Pelotas, RS 96010-900, Brazil.
  • Vizzotto M; Embrapa Temperate Agriculture, Pelotas, RS 96010-971, Brazil.
  • Mertens-Talcott S; Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843-2253, United States.
  • Talcott S; Department of Nutrition and Food Science, Texas A&M University, College Station, TX 77843-2253, United States.
  • Gomes CL; Department of Biological & Agricultural Engineering, Texas A&M University, College Station, TX 77843-2117, United States. Electronic address: carmen@tamu.edu.
Food Chem ; 240: 396-404, 2018 Feb 01.
Article em En | MEDLINE | ID: mdl-28946289
Guabiroba fruit has been highlighted for its high phytochemical content, particularly of phenolic compounds. The stability, bioavailability, and bioactivity of these compounds can be enhanced by nanoencapsulation, to improve functionality. Poly(d,l-lactic-co-glycolic) acid (PLGA) nanoparticles containing phenolic extract of guabiroba (GPE) were synthesized by an adapted emulsion-evaporation method and their physico-chemical and functional properties were studied at two lactic to glycolic acid ratios (50:50 and 65:35). Higher (P<0.05) or equivalent antioxidant capacity compared to free GPE were observed for GPE-loaded nanoparticles. Free extract and PLGA nanoparticles were effective inhibitors of Listeria innocua, with lower (P<0.05) GPE concentrations required for inhibition when nanoencapsulated. Also, reduction of ROS generation in non-cancer cells was achieved with lower GPE concentrations (P<0.05) after encapsulation. These results suggest that PLGA nanoparticles can be used as a delivery system for phenolic compounds at lower levels than originally required for enhanced functional properties.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Frutas Limite: Humans Idioma: En Revista: Food Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Frutas Limite: Humans Idioma: En Revista: Food Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido