Cytotoxic Constituents from Daphnia pulex.

Perez Gutierrez, R M; Lule P, R

Perez Gutierrez, R M; Lule P, R.

Afiliação

Perez Gutierrez RM; a Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industias extractivas IPN, Col. Torres Lindavista, Mexico D.F., Mexico.
Lule P R; a Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industias extractivas IPN, Col. Torres Lindavista, Mexico D.F., Mexico.

Pharm Biol ; 43(4): 313-316, 2005.

Article em En | MEDLINE | ID: mdl-28925836

RESUMO

Activity-guided fractionation of the methanol extract of Daphnia pulex. (Leydig) using the MTT assay and P-388, A549, KB, and HT-29 cell lines permitted the isolation of four known glyceroglycolipid compounds: (2S.)-1-O.-(7Z.,10Z.,13Z.)-hexadecatrienoyl-2-O.-(7Z.,10Z.)-hexadecadienoyl-3-O.-ß.-D-galactopyranosyl-sn.-glycerol, (2S.)-1-O.-(7Z.,10Z.)-hexadecadienoyl-2-O.-(7Z.,10Z.)-hexadecadienoyl-3-O.-ß.-D-galactopyranosyl-sn.-glycerol, (2S.)-1-O.-(7Z.,10Z.)-hexadecadienolyl-2-O.-linolenoyl-3-O.-ß.-D-galactopyranosyl-sn.-glycerol, and (2S.)-1-O.-(9Z., 12Z.)-octadecadienoyl-2-O.-(7Z.,10Z.)-hexadecadienoyl-3-O.-(α.-D-galactopyranosyl(1-6)-ß.-D-galactopyranosyl-sn.-glycerol. All the isolates were found to be moderately cytotoxic (ED50 < 4 µg/ml) toward P-388, A549, KB, and HT-29 cell lines.

Palavras-chave

Cytotoxic activity; Daphnia pulex; digalactosyl diacylglycerols; monogalactosyl diacylglycerols

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Pharm Biol Ano de publicação: 2005 Tipo de documento: Article País de afiliação: México País de publicação: Reino Unido

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