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IGF2 stimulates fetal growth in a sex- and organ-dependent manner.
White, Veronica; Jawerbaum, Alicia; Mazzucco, Maria Belen; Gauster, Martin; Desoye, Gernot; Hiden, Ursula.
Afiliação
  • White V; Laboratory of Reproduction and Metabolism, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  • Jawerbaum A; Laboratory of Reproduction and Metabolism, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  • Mazzucco MB; Laboratory of Reproduction and Metabolism, Center for Pharmacological and Botanical Studies, CEFyBO-CONICET, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
  • Gauster M; Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
  • Desoye G; Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.
  • Hiden U; Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.
Pediatr Res ; 83(1-1): 183-189, 2018 01.
Article em En | MEDLINE | ID: mdl-28910276
BackgroundInsulin-like growth factor 2 (IGF2) is a key determinant of fetal growth, and the altered expression of IGF2 is implicated in fetal growth disorders and maternal metabolic derangements including gestational diabetes. Here we studied how increased levels of IGF2 in late pregnancy affect fetal growth.MethodsWe employed a rat model of repeated intrafetal IGF2 administration in late pregnancy, i.e., during GD19-GD21, and measured the consequences on fetal organ weight and expression of insulin/IGF-axis components.ResultsIGF2 treatment tended to increase fetal weight, but only weight increase of the fetal stomach reached significance (+33±9%; P<0.01). Sex-dependent data analysis revealed a sexual dimorphism of IGF2 action. In male fetuses, IGF2 administration significantly increased fetal weight (+13±3%; P<0.05) and weight of fetal stomach (+42±10%; P<0.01), intestine (+26±5%; P<0.05), liver (+13±4%; P<0.05), and pancreas (+25±8%; P<0.05). Weights of heart, lungs, and kidneys were unchanged. In female fetuses, IGF2 increased only stomach weight (+26±9%; P<0.05). Furthermore, gene expression of insulin/IGF axis in the heart, lungs, liver, and stomach was more sensitive toward IGF2 treatment in male than in female fetuses.ConclusionData suggest that elevated circulating IGF2 in late pregnancy predominantly stimulates organ growth of the digestive system, and male fetuses are more susceptible toward the IGF2 effects than female fetuses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like II / Regulação da Expressão Gênica no Desenvolvimento / Sistema Digestório Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Pediatr Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like II / Regulação da Expressão Gênica no Desenvolvimento / Sistema Digestório Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Pregnancy Idioma: En Revista: Pediatr Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Argentina País de publicação: Estados Unidos