Mechanochemical enzymatic resolution of N-benzylated-ß3-amino esters.
Beilstein J Org Chem
; 13: 1728-1734, 2017.
Article
em En
| MEDLINE
| ID: mdl-28904616
The use of mechanochemistry to carry out enantioselective reactions has been explored in the last ten years with excellent results. Several chiral organocatalysts and even enzymes have proved to be resistant to milling conditions, which allows for rather efficient enantioselective transformations under ball-milling conditions. The present article reports the first example of a liquid-assisted grinding (LAG) mechanochemical enzymatic resolution of racemic ß3-amino esters employing Candida antarctica lipase B (CALB) to afford highly valuable enantioenriched N-benzylated-ß3-amino acids in good yields. Furthermore the present protocol is readily scalable.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
México
País de publicação:
Alemanha