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Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome.
Bonamigo, Thaliny; Campos, Jaqueline Ferreira; Oliveira, Alex Santos; Torquato, Heron Fernandes Vieira; Balestieri, José Benedito Perrella; Cardoso, Claudia Andrea Lima; Paredes-Gamero, Edgar Julian; de Picoli Souza, Kely; Dos Santos, Edson Lucas.
Afiliação
  • Bonamigo T; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Campos JF; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Oliveira AS; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Torquato HFV; Faculty of Pharmacy, Braz Cubas University, Francisco Rodrigues Filho Avenue, Mogi das Cruzes, SP, Brazil.
  • Balestieri JBP; Department of Biochemistry, Federal University of São Paulo, R. Três de Maio 100, São Paulo, SP, Brazil.
  • Cardoso CAL; Research Group on Biotechnology and Bioprospecting Applied to Metabolism (GEBBAM), Federal University of Grande Dourados, Dourados, MS, Brazil.
  • Paredes-Gamero EJ; Course of Chemistry, State University of Mato Grosso do Sul, Dourados, MS, Brazil.
  • de Picoli Souza K; Course of Chemistry, State University of Mato Grosso do Sul, Dourados, MS, Brazil.
  • Dos Santos EL; Center for Interdisciplinary Research Biochemistry, University of Mogi das Cruzes, Av. Dr. Cândido Xavier de Almeida Souza, Mogi das Cruzes, SP, Brazil.
PLoS One ; 12(9): e0183983, 2017.
Article em En | MEDLINE | ID: mdl-28898258
Propolis is a complex bioactive mixture produced by bees, known to have different biological activities, especially in countries where there is a rich biodiversity of plant species. The objective of this study was to determine the chemical composition and evaluate the antioxidant and cytotoxic properties of Brazilian propolis from the species Plebeia droryana and Apis mellifera found in Mato Grosso do Sul, Brazil. In the ethanolic extracts of P. droryana propolis (ExEP-P) and A. mellifera (ExEP-A) acids, phenolic compounds, terpenes and tocopherol were identified as major compounds. Both extracts presented antioxidant activity against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, the maximum activities being 500 µg/mL (ExEP-P) and 300 µg/mL (ExEP-A). However, only ExEP-A was able to inhibit lipid peroxidation induced by the oxidizing agent 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH), which inhibited oxidative hemolysis and reduced the levels of malondialdehyde (MDA) in human erythrocytes for 4 h of incubation. The extracts also reduced the cell viability of the K562 erythroleukemia tumour line, with a predominance of necrotic death. Thus, it is concluded that the propolis produced by P. droryana and A. mellifera contain important compounds capable of minimizing the action of oxidizing substances in the organism and reducing the viability of erythroleukemia cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Himenópteros / Antioxidantes Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Himenópteros / Antioxidantes Limite: Animals / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos