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Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2.
Velasco-Aguirre, Carolina; Morales-Zavala, Francisco; Salas-Huenuleo, Edison; Gallardo-Toledo, Eduardo; Andonie, Oscar; Muñoz, Luis; Rojas, Ximena; Acosta, Gerardo; Sánchez-Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Albericio, Fernando; Kogan, Marcelo Javier.
Afiliação
  • Velasco-Aguirre C; Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
  • Morales-Zavala F; Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
  • Salas-Huenuleo E; Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
  • Gallardo-Toledo E; Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
  • Andonie O; Sección Metrologia Química, Comisión Chilena de Energía Nuclear, CCHEN, Nueva Bilbao 12501, La Reina, Santiago, Chile.
  • Muñoz L; Sección Metrologia Química, Comisión Chilena de Energía Nuclear, CCHEN, Nueva Bilbao 12501, La Reina, Santiago, Chile.
  • Rojas X; Sección Metrologia Química, Comisión Chilena de Energía Nuclear, CCHEN, Nueva Bilbao 12501, La Reina, Santiago, Chile.
  • Acosta G; Department of Inorganic & Organic Chemistry, University of Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.
  • Sánchez-Navarro M; CIBER-BBN, Networking Centre on Bioengineering, Biomaterials & Nanomedicine, Barcelona Science Park, 08028 Barcelona, Spain.
  • Giralt E; Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science & Technology, Baldiri Reixac 10, 08028 Barcelona (Spain).
  • Araya E; Department of Inorganic & Organic Chemistry, University of Barcelona, Martí i Franquès 1, 08028 Barcelona, Spain.
  • Albericio F; Institute for Research in Biomedicine (IRB Barcelona) Barcelona Institute of Science & Technology, Baldiri Reixac 10, 08028 Barcelona (Spain).
  • Kogan MJ; Departamento de Ciencias Quimicas, Facultad de Ciencias Exactas, Universidad Andres Bello, Republica 275, 8370146 Santiago, Chile.
Nanomedicine (Lond) ; 12(20): 2503-2517, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28882086
AIM: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. MATERIALS & METHODS: GNRs were synthesized and modified using polyethylene glycol and Angiopep-2 (GNR-PEG-Angiopep-2). The physicochemical properties, in vitro cytotoxicity and ex vivo biodistribution of the conjugate were examined. RESULTS: GNR-PEG-Angiopep-2 was stable over the following days, and the different concentrations that were tested did not affect the viability of microvascular endothelial cells. The conjugation of Angiopep-2 to GNRs enhanced the endocytosis of these particles (in vitro) and the accumulation in brains (in vivo), when compared with GNRs modified only with PEG. CONCLUSION: This study provides evidence that Angiopep-2 improves the delivery of GNRs to the brain parenchyma. This property is highly relevant for future applications of GNRs as platforms for photothermal and theranostic purposes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Sistema Nervoso Central / Nanotubos / Ouro Limite: Animals / Humans / Male Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Sistema Nervoso Central / Nanotubos / Ouro Limite: Animals / Humans / Male Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido