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Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment.
Gomes, Graziela Scheuer; Maciel, Tamara Ramos; Piegas, Eduarda Martini; Michels, Luana Roberta; Colomé, Letícia Marques; Freddo, Rodrigo José; Ávila, Daiana Silva de; Gundel, Andre; Haas, Sandra Elisa.
Afiliação
  • Gomes GS; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Maciel TR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Piegas EM; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Michels LR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Colomé LM; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Freddo RJ; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Ávila DS; Curso de Farmácia, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Gundel A; Programa de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, UNIPAMPA, Uruguaiana, RS, 97500-970, Brazil.
  • Haas SE; Campus Bagé, Universidade Federal do Pampa, UNIPAMPA, Travessa 45, 1650, Bagé, RS, 96413-170, Brazil.
AAPS PharmSciTech ; 19(2): 551-564, 2018 Feb.
Article em En | MEDLINE | ID: mdl-28875471
Quinine, a treatment used in chloroquine-resistant falciparum malaria, was loaded into poly(ɛ-caprolactone) or Eudragit® RS100 nanocapsules using Curcuma oil as the oil-based core. Until now, the effect of cationic nanocapsules on malaria has not been reported. A 24 factorial design was adopted using, as independent variables, the concentration of Curcuma oil, presence of quinine, type of polymer, and aqueous surfactant. Diameter, zeta potential, and pH were the responses studied. The formulations were also evaluated for drug content, encapsulation efficiency, photostability, and antimalarial activity against Plasmodium berghei-infected mice. The type of polymer influenced all of the responses studied. Quinine-loaded Eudragit® RS100 (F13) and PCL nanocapsules (F9), both with polysorbate 80 coating, showed nanometric particle size, positive zeta potential, neutral pH, high drug content, and quinine photoprotection ability; thus, these nanocapsules were selected for in vivo tests. Both formulations showed lower levels of parasitemia from the beginning of the experiment (5.78 ± 3.60 and 4.76 ± 3.46% for F9 and F13, respectively) and highest survival mean time (15.3 ± 2.0 and 14.9 ± 5.6 days for F9 and F13, respectively). F9 and F13 showed significant survival curve compared to saline, thus demonstrating that nanoencapsulation improved bioefficacy of QN and co-encapsulated curcuminoids, regardless of the surface charge.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinina / Óleos de Plantas / Curcuma / Malária / Antimaláricos Limite: Animals Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinina / Óleos de Plantas / Curcuma / Malária / Antimaláricos Limite: Animals Idioma: En Revista: AAPS PharmSciTech Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos