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Immune status of patients with haemophilia A before exposure to factor VIII: first results from the HEMFIL study.
Jardim, Letícia L; Chaves, Daniel G; Silveira-Cassette, Amanda C O; Simões E Silva, Ana Cristina; Santana, Marcio P; Cerqueira, Monica H; Prezotti, Alessandra; Lorenzato, Claudia; Franco, Vivian; van der Bom, Johanna G; Rezende, Suely M.
Afiliação
  • Jardim LL; Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Chaves DG; Fundação HEMOMINAS, Belo Horizonte, Minas Gerais, Brazil.
  • Silveira-Cassette ACO; Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Simões E Silva AC; Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Santana MP; Fundação HEMOMINAS, Belo Horizonte, Minas Gerais, Brazil.
  • Cerqueira MH; Instituto de Hematologia Arthur de Siqueira Cavalcanti (HEMORIO), Rio de Janeiro, Brazil.
  • Prezotti A; Centro de Hematologia e Hemoterapia do Espírito Santo (HEMOES), Vitória, Espírito Santo, Brazil.
  • Lorenzato C; Centro de Hematologia e Hemoterapia do Paraná (HEMEPAR), Curitiba, Paraná, Brazil.
  • Franco V; Centro de Hematologia e Hemoterapia de Santa Catarina (HEMOSC), Florianópolis, Santa Catarina, Brazil.
  • van der Bom JG; Centre for Clinical Transfusion Research, Sanquin & Department of Clinical Epidemiology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.
  • Rezende SM; Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Br J Haematol ; 178(6): 971-978, 2017 09.
Article em En | MEDLINE | ID: mdl-28836262
Previous cross-sectional studies showed that some patients with haemophilia A (HA) without inhibitor presented a pro-inflammatory profile during factor VIII (FVIII) replacement therapy. Furthermore, an anti-inflammatory/regulatory state was described in HA patients after inhibitor development. However, no study investigated the levels of these biomarkers before exposure to exogenous FVIII. This study investigated the immunological profile of previously untreated patients (PUPs) with HA in comparison with non-haemophiliac boys. A panel of chemokines and cytokines was evaluated in the plasma of 40 PUPs with HA and 47 healthy controls. The presence of microparticles was assessed in the plasma of 32 PUPs with HA and 47 healthy controls. PUPs with HA presented higher levels of CXCL8 (IL8), IL6, IL4, IL10, IL2, IL17A (IL17), and lower levels of CXCL10 (IP-10) and CCL2 (MCP-1) than the age-matched healthy controls (P < 0·05). We also observed higher levels of microparticles derived from endothelium, erythrocytes, platelets, leucocytes, neutrophils, and T lymphocytes in patients in comparison with controls (P < 0·05). Compared with controls, PUPs with HA presented a distinct immunological profile, characterized by a prominent pro-inflammatory status that appears to be regulated by IL4 and IL10.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Citocinas / Hemofilia A Tipo de estudo: Clinical_trials / Observational_studies Limite: Humans / Infant / Male Idioma: En Revista: Br J Haematol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator VIII / Citocinas / Hemofilia A Tipo de estudo: Clinical_trials / Observational_studies Limite: Humans / Infant / Male Idioma: En Revista: Br J Haematol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido