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Transporter genes ABCG2 rs2231142 and ABCB1 rs1128503 polymorphisms and atorvastatin response in Chilean subjects.
Prado, Y; Zambrano, T; Salazar, L A.
Afiliação
  • Prado Y; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.
  • Zambrano T; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.
  • Salazar LA; Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco, Chile.
J Clin Pharm Ther ; 43(1): 87-91, 2018 Feb.
Article em En | MEDLINE | ID: mdl-28833323
WHAT IS KNOWN AND OBJECTIVE: Statins are first-line therapy for reducing high cholesterol levels. However, response to these drugs shows high interindividual variability. We aimed to investigate the influence of two single nucleotide polymorphisms (SNP) (ABCB1 rs1128503 and ABCG2 rs2231142) in the ABC transporter genes on response to short-term low-dose atorvastatin in Chilean hypercholesterolaemic patients. METHODS: We studied 127 Chilean hypercholesterolaemic patients treated with 10 mg/d atorvastatin for 4 weeks. The lipid profile was determined before and after drug administration. Genotyping of the rs1128503 and rs2231142 variants was performed using TaqMan® Drug Metabolism Genotyping Assays. RESULTS AND DISCUSSION: Genotype distribution for all polymorphisms investigated was consistent with the Hardy-Weinberg equilibrium. Atorvastatin reduced TC, LDL-C and TG concentrations (P<.05), whereas HDL-C levels were found to be increased (P<.05). Minor allele frequencies for rs1128503 and rs2231142 variants were 0.453 and 0.075, respectively. In this study, patients prescribed with short-term low-dose atorvastatin and carrying ABCB1 (rs1128503) or ABCG2 (rs2231142) SNPs did not show differences in LDL-C response (P>.05). WHAT IS NEW AND CONCLUSION: The ABCB1 SNP was not associated with response to atorvastatin in Chilean subjects. The few ABCG2 421A homozygotes did not allow meaningful inferences to be made for this polymorphism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Atorvastatina / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Hipercolesterolemia / Proteínas de Neoplasias Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Chile Idioma: En Revista: J Clin Pharm Ther Assunto da revista: FARMACIA / TERAPEUTICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Atorvastatina / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Hipercolesterolemia / Proteínas de Neoplasias Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Chile Idioma: En Revista: J Clin Pharm Ther Assunto da revista: FARMACIA / TERAPEUTICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Chile País de publicação: Reino Unido