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Intrauterine and lactation exposure to fluoxetine blunted in the offspring the aortic adaptive response induced by acute restraint stress.
Marques, Bruno V D; Higashi, Carolina M; da S Novi, Daniella R B; Zanluqui, Nagela G; Gregório, Thais F; Pinge-Filho, Phileno; Gerardin, Daniela C C; Pelosi, Gislaine G; Moreira, Estefânia G; Ceravolo, Graziela S.
Afiliação
  • Marques BVD; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Higashi CM; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • da S Novi DRB; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Zanluqui NG; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Gregório TF; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Pinge-Filho P; Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Gerardin DCC; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Pelosi GG; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Moreira EG; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil.
  • Ceravolo GS; Department of Physiological Sciences, Biological Sciences Center, State University of Londrina, Parana, Brazil. Electronic address: gsceravolo@uel.br.
Eur J Pharmacol ; 813: 147-152, 2017 Oct 15.
Article em En | MEDLINE | ID: mdl-28822853
Selective serotonin reuptake inhibitors are the most widely prescribed antidepressants to women during pregnancy. Maternal treatment with fluoxetine can expose fetuses and neonates to higher levels of serotonin that plays a role in stress response. Thus, the aim of the study was to evaluate whether maternal treatment with fluoxetine interferes with aorta reactivity of adult male offspring after acute restraint stress. Wistar rats were gavaged with fluoxetine (5mg/kg/day) or water (control) during pregnancy and lactation. The experiments were performed in adult male offspring, treated or not with reserpine (4mg/Kg, ip, 28h before the experimental protocol). Fluoxetine and control rats were submitted to a single restraint stress session (ST) for 1h. Curves to phenylephrine were performed in thoracic aorta with endothelium. Aortic nitric oxide (NOx) were evaluated by the Griess method. The aortic contraction induced by phenylephrine was similar between control and fluoxetine rats. The acute stress reduced contraction in aorta of control ST compared to control, and L-NAME equaled this response. In fluoxetine rats, ST did not change the aortic constriction. Reserpine treatment restored the vasoconstriction in control ST, but did not interfere with aortic contraction in control, fluoxetine or fluoxetine ST. The NOx concentration was higher in aortas from control ST than control rats, and reserpine reduced NOx levels of control ST. The NOx concentration was similar between fluoxetine and fluoxetine ST rats, treated or not with reserpine. In conclusion, maternal treatment with fluoxetine blunted acute restraint stress-induced NO system activation and aortic adaptation in adult offspring.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Efeitos Tardios da Exposição Pré-Natal / Estresse Psicológico / Útero / Lactação / Fluoxetina Tipo de estudo: Guideline Limite: Animals / Pregnancy Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Efeitos Tardios da Exposição Pré-Natal / Estresse Psicológico / Útero / Lactação / Fluoxetina Tipo de estudo: Guideline Limite: Animals / Pregnancy Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Holanda