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Tetracarboxy-phthalocyanines: From excited state dynamics to photodynamic inactivation against Bovine herpesvirus type 1.
Cocca, Leandro H Z; Oliveira, Taise M A; Gotardo, Fernando; Teles, Amanda V; Menegatti, Ricardo; Siqueira, Jonathas P; Mendonça, Cleber R; Bataus, Luiz A M; Ribeiro, Anderson O; Souza, Thalita F M; Souza, Guilherme R L; Gonçalves, Pablo J; De Boni, Leonardo.
Afiliação
  • Cocca LHZ; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
  • Oliveira TMA; Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.
  • Gotardo F; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
  • Teles AV; Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.
  • Menegatti R; Instituto de Farmácia, Universidade Federal de Goiás, Goiânia, Brazil.
  • Siqueira JP; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
  • Mendonça CR; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil.
  • Bataus LAM; Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil.
  • Ribeiro AO; Center for Natural Sciences and Humanities, Federal University of ABC (UFABC), Santo André, SP, Brazil.
  • Souza TFM; Center for Natural Sciences and Humanities, Federal University of ABC (UFABC), Santo André, SP, Brazil.
  • Souza GRL; Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Brazil; Programa de Pós-graduação em Ciência Animal, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address: grlino@gmail.com.
  • Gonçalves PJ; Instituto de Física, Universidade Federal de Goiás, Goiânia, Brazil; Programa de Pós-graduação em Química, Universidade Federal de Goiás, Goiânia, Brazil. Electronic address: pablo@ufg.br.
  • De Boni L; Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, Brazil. Electronic address: deboni@ifsc.usp.br.
J Photochem Photobiol B ; 175: 1-8, 2017 Oct.
Article em En | MEDLINE | ID: mdl-28822848
Herein we present the excited state dynamic of zinc and aluminum tetracarboxy-phthalocyanines (ZnPc and AlPc) and its application in the photodynamic inactivation (PDI) of Bovine herpesvirus type 1 (BoHV-1) in vitro. The excited state dynamic provides valuable data to describe the excited state properties of potential optical limiters and/or photosensitizers (PSs), such as: the excited state cross-sections, fluorescence lifetime and triplet state quantum yield. The excited state characterization was performed using three different Z-scan techniques: Single Pulse, White Light Continuum and Pulse Train. Considering the photodynamic inactivation of BoHV-1, an initial viral suspension containing 105.75TCID50/mL was incubated with the PSs for 1h at 37°C under agitation and protected from light. The samples were placed in microtiter plates and irradiated (180mW/cm2). During irradiation, a sample was taken every 15min and the viability of the virus was evaluated. The results show that both phthalocyanines were efficient against viruses. However, a higher photodynamic efficiency was observed by ZnPc, which can be attributed to its higher triplet and singlet quantum yields. The results presented here are important for animal health (treatment of BoHV-1) and also open up a field of studies to use AlPc and ZnPc as potential agents against a wide range of microorganisms of veterinary interest.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Fármacos Fotossensibilizantes / Herpesvirus Bovino 1 / Inativação de Vírus / Indóis Limite: Animals Idioma: En Revista: J Photochem Photobiol B Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Fármacos Fotossensibilizantes / Herpesvirus Bovino 1 / Inativação de Vírus / Indóis Limite: Animals Idioma: En Revista: J Photochem Photobiol B Assunto da revista: BIOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Suíça