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Cytokine Signature in End-Stage Renal Disease Patients on Hemodialysis.
Rios, Danyelle Romana Alves; Pinheiro, Melina Barros; de Oliveira Junior, Wander Valadares; Braga Gomes, Karina; Carvalho, Andréa Teixeira; Martins-Filho, Olindo Assis; Simões E Silva, Ana Cristina; Dusse, Luci Maria Sant'Ana.
Afiliação
  • Rios DRA; Campus Centro Oeste, Federal University of Sao Joao del-Rei, Divinópolis, MG, Brazil.
  • Pinheiro MB; Campus Centro Oeste, Federal University of Sao Joao del-Rei, Divinópolis, MG, Brazil.
  • de Oliveira Junior WV; Campus Centro Oeste, Federal University of Sao Joao del-Rei, Divinópolis, MG, Brazil.
  • Braga Gomes K; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Carvalho AT; Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
  • Martins-Filho OA; Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
  • Simões E Silva AC; Department of Pediatrics, Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
  • Dusse LMS; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Dis Markers ; 2017: 9678391, 2017.
Article em En | MEDLINE | ID: mdl-28819334
Hemodialysis is a modality of blood filtration in which accumulated toxins and water are removed from the body. This treatment is indicated for patients at the end stage of renal disease. Vascular access complications are responsible for 20-25% of all hospitalizations in dialyzed patients. The occurrence of thrombosis in the vascular access is a serious problem that may severely compromise or even make the hemodialysis impossible, which is vital for the patient. The aim of this study was to investigate inflammatory profile in patients undergoing hemodialysis as well as the association between these alterations and vascular access thrombosis. A total of 195 patients undergoing hemodialysis have been evaluated; of which, 149 patients had not experienced vascular access thrombosis (group I) and 46 patients had previously presented this complication (group II). Plasma levels of cytokines including interleukin (IL-) 2, IL-4, IL-5, IL-10, TNF-α, and IFN-γ were measured by cytometric bead array. Our results showed that patients with previous thrombotic events (group II) had higher levels of the IL-2, IL-4, IL-5, and IFN-γ when compared to those in group I. Furthermore, a different cytokine signature was detected in dialyzed patients according to previous occurrences or not of thrombotic events, suggesting that elevated levels of T-helper 1 and T-helper 2 cytokines might, at least in part, contribute to this complication.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Citocinas / Falência Renal Crônica Tipo de estudo: Etiology_studies / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Assunto da revista: BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Citocinas / Falência Renal Crônica Tipo de estudo: Etiology_studies / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Assunto da revista: BIOQUIMICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos