Your browser doesn't support javascript.
loading
Comparison between parameters of muscle performance and inflammatory biomarkers of non-sarcopenic and sarcopenic elderly women.
Lustosa, Lygia Paccini; Batista, Patrícia Parreira; Pereira, Daniele Sirineu; Pereira, Leani Souza Máximo; Scianni, Aline; Ribeiro-Samora, Giane Amorim.
Afiliação
  • Lustosa LP; Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte.
  • Batista PP; Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte.
  • Pereira DS; Physical Therapy Department, Universidade Federal de Alfenas, Alfenas, Brazil.
  • Pereira LSM; Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte.
  • Scianni A; Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte.
  • Ribeiro-Samora GA; Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte.
Clin Interv Aging ; 12: 1183-1191, 2017.
Article em En | MEDLINE | ID: mdl-28814844
BACKGROUND: Sarcopenia is a multifactorial geriatric syndrome with complex interrelationships. Increased plasma levels of inflammatory mediators increase the catabolic stimuli of the musculature, thereby causing a decrease in mass and muscular function. OBJECTIVE: The objective of this study was to compare the performance of the knee extensors test (by isokinetic dynamometer) and plasma levels of interleukin-6 (IL-6) and soluble receptors of tumor necrosis factor alpha (sTNFR1) between sarcopenics and non-sarcopenics community-dwelling elderly women residents of Brazil. MATERIAL AND METHODS: The diagnosis of sarcopenia included measurements of body composition (by densitometry with dual energy source of X-ray), handgrip strength (by Jamar® dynamometer), and the usual gait velocity according to the recommendations of the European Working Group on Sarcopenia in Older People. In both sarcopenics and non-sarcopenics elderly women, we evaluated the muscle function by knee extensors test (using an isokinetic dynamometer Byodex System 4 Pro®) at angular speeds of 60°/s and 180°/s) and also we evaluated the plasma concentrations of IL-6 and sTNFR1. Comparisons of muscle performance between groups were carried out using mixed factorial ANOVA with post hoc Bonferroni test; sTNFR1 and IL-6 variables were analyzed by applying Mann-Whitney U test. RESULTS: Statistical differences were observed between groups regarding muscle power (P=0.01), total work adjusted to body weight (P=0.01) at a rate of 180°/s, and plasma levels of sTNFR1 (P=0.01). CONCLUSION: Sarcopenic elder women showed lower performance of the lower limbs, especially at a higher speed, predisposing these older women to greater vulnerability in functional activities that require agility and postural stability. Plasma levels of sTNFR1 were higher for non-sarcopenics elderlies. However, due to the observational nature of the study, it was impossible to infer causality among the variables surveyed.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mediadores da Inflamação / Força da Mão / Sarcopenia / Marcha Tipo de estudo: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Clin Interv Aging Assunto da revista: GERIATRIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Nova Zelândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mediadores da Inflamação / Força da Mão / Sarcopenia / Marcha Tipo de estudo: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Clin Interv Aging Assunto da revista: GERIATRIA Ano de publicação: 2017 Tipo de documento: Article País de publicação: Nova Zelândia