Depsidones and an α-pyrone derivative from Simplicillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf [corrected].
Phytochemistry
; 143: 115-123, 2017 11.
Article
em En
| MEDLINE
| ID: mdl-28803995
Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 µg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 µg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pironas
/
Euphorbiaceae
/
Hevea
/
Depsídeos
/
Lactonas
/
Antibacterianos
/
Antifúngicos
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Tailândia
País de publicação:
Reino Unido