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Depsidones and an α-pyrone derivative from Simplicillium sp. PSU-H41, an endophytic fungus from Hevea brasiliensis leaf [corrected].
Saetang, Praphatsorn; Rukachaisirikul, Vatcharin; Phongpaichit, Souwalak; Preedanon, Sita; Sakayaroj, Jariya; Borwornpinyo, Suparerk; Seemakhan, Sawinee; Muanprasat, Chatchai.
Afiliação
  • Saetang P; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
  • Rukachaisirikul V; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand. Electronic address: vatcharin.r@psu.ac.th.
  • Phongpaichit S; Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
  • Preedanon S; National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand.
  • Sakayaroj J; National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand.
  • Borwornpinyo S; Department of Biotechnology, Faculty of Science, Mahidol University, Rajathevi, Bangkok 10400, Thailand.
  • Seemakhan S; Excellent Center of Drug Discovery and Department of Physiology, Faculty of Science, Mahidol University, Rajathevi, Bangkok 10400, Thailand.
  • Muanprasat C; Excellent Center of Drug Discovery and Department of Physiology, Faculty of Science, Mahidol University, Rajathevi, Bangkok 10400, Thailand.
Phytochemistry ; 143: 115-123, 2017 11.
Article em En | MEDLINE | ID: mdl-28803995
Nine previously undescribed depsidones (simplicildones A-I) and one previously undescribed α-pyrone (simplicilopyrone) were isolated from the endophytic fungus Simplicillium sp. PSU-H41 along with 11 known compounds. Their structures were established by extensive spectroscopic analysis. Simplicildone A and known botryorhodine C displayed weak antibacterial against Staphylococcus aureus with equal MIC values of 32 µg/mL. Additionally, botryorhodine C was active against methicillin-resistant S. aureus with the same MIC value. Simplicildone C exhibited weak antifungal activity against Cryptococcus neoformans with an MIC value of 32 µg/mL. In addition, simplicildones A and C and botryorhodine C were noncytotoxic against noncancerous Vero cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pironas / Euphorbiaceae / Hevea / Depsídeos / Lactonas / Antibacterianos / Antifúngicos Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Phytochemistry Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Tailândia País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pironas / Euphorbiaceae / Hevea / Depsídeos / Lactonas / Antibacterianos / Antifúngicos Limite: Animals País/Região como assunto: America do sul / Brasil Idioma: En Revista: Phytochemistry Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Tailândia País de publicação: Reino Unido