Combustion-derived nanoparticles, the neuroenteric system, cervical vagus, hyperphosphorylated alpha synuclein and tau in young Mexico City residents.

Calderón-Garcidueñas, Lilian; Reynoso-Robles, Rafael; Pérez-Guillé, Beatriz; Mukherjee, Partha S; Gónzalez-Maciel, Angélica

Calderón-Garcidueñas, Lilian; Reynoso-Robles, Rafael; Pérez-Guillé, Beatriz; Mukherjee, Partha S; Gónzalez-Maciel, Angélica.

Afiliação

Calderón-Garcidueñas L; The University of Montana, Missoula, MT 59812, USA; Universidad del Valle de México, Mexico City 14370, Mexico. Electronic address: lilian.calderon-garciduenas@umontana.edu.
Reynoso-Robles R; Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
Pérez-Guillé B; Instituto Nacional de Pediatría, Mexico City 04530, Mexico.
Mukherjee PS; Mathematics Department, Boise State University, Boise, Idaho, USA.
Gónzalez-Maciel A; Instituto Nacional de Pediatría, Mexico City 04530, Mexico.

Environ Res ; 159: 186-201, 2017 11.

Article em En | MEDLINE | ID: mdl-28803148

RESUMO

Mexico City (MC) young residents are exposed to high levels of fine particulate matter (PM2.5), have high frontal concentrations of combustion-derived nanoparticles (CDNPs), accumulation of hyperphosphorylated aggregated α-synuclein (α-Syn) and early Parkinson's disease (PD). Swallowed CDNPs have easy access to epithelium and submucosa, damaging gastrointestinal (GI) barrier integrity and accessing the enteric nervous system (ENS). This study is focused on the ENS, vagus nerves and GI barrier in young MC v clean air controls. Electron microscopy of epithelial, endothelial and neural cells and immunoreactivity of stomach and vagus to phosphorylated É-synuclein Ser129 and Hyperphosphorylated-Tau (Htau) were evaluated and CDNPs measured in ENS. CDNPs were abundant in erythrocytes, unmyelinated submucosal, perivascular and intramuscular nerve fibers, ganglionic neurons and vagus nerves and associated with organelle pathology. ÉSyn and Htau were present in 25/27 MC gastric,15/26 vagus and 18/27 gastric and 2/26 vagus samples respectively. We strongly suggest CDNPs are penetrating and damaging the GI barrier and reaching preganglionic parasympathetic fibers and the vagus nerve. This work highlights the potential role of CDNPs in the neuroenteric hyperphosphorylated É-Syn and tau pathology as seen in Parkinson and Alzheimer's diseases. Highly oxidative, ubiquitous CDNPs constitute a biologically plausible path into Parkinson's and Alzheimer's pathogenesis.

Assuntos

Poluentes Atmosféricos/toxicidade; Intestino Delgado/efeitos dos fármacos; Nanopartículas/toxicidade; Nervo Vago/efeitos dos fármacos; Emissões de Veículos/toxicidade; Adolescente; Adulto; Animais; Biomarcadores/análise; Criança; Cidades; Cães; Feminino; Humanos; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/patologia; Mucosa Intestinal/ultraestrutura; Intestino Delgado/patologia; Intestino Delgado/ultraestrutura; Masculino; México; Microscopia Eletrônica de Transmissão; Fosforilação; RNA Mensageiro/análise; Junções Íntimas/efeitos dos fármacos; Junções Íntimas/patologia; Junções Íntimas/ultraestrutura; Nervo Vago/metabolismo; Nervo Vago/ultraestrutura; Adulto Jovem; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo; Proteínas tau/genética; Proteínas tau/metabolismo

Palavras-chave

Alpha synuclein; Alzheimer; Children; Combustion-derived nanoparticles; GI barrier; Hyperphosphorylated tau; Mexico City; Neuroenteric system; Parkinson; Vagus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nervo Vago / Emissões de Veículos / Poluentes Atmosféricos / Nanopartículas / Intestino Delgado Limite: Adolescent / Adult / Animals / Child / Female / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Environ Res Ano de publicação: 2017 Tipo de documento: Article País de publicação: Holanda

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