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Side Effects of Indomethacin in Refractory Post-traumatic Intracranial Hypertension: A comprehensive case study and review.
Godoy, Daniel Agustín; Suarez, Pablo David Guerrero; Moscote-Salazar, Luis Rafael; Napoli, Mario Di.
Afiliação
  • Godoy DA; Intensive Care Unit, San Juan Bautista Hospital, Catamarca, Argentina.
  • Suarez PDG; Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina.
  • Moscote-Salazar LR; Department of Neurosurgery, ISSEMyM Medical Center, Toluca, México.
  • Napoli MD; Intensive Care Unit, University Clinic, Puerto Montt, Chile.
Bull Emerg Trauma ; 5(3): 143-151, 2017 Jul.
Article em En | MEDLINE | ID: mdl-28795057
Intracranial hypertension (IH) is one of the final pathways of acute brain injury. In severe traumatic brain injury (sTBI), it independently predicts poor outcomes. Its control represents a key aspect of the management. Lack of response to conventional therapies signals a state of ''refractory IH'', with an associated mortality rate of 80-100%. In such cases, hypothermia, barbiturates at high doses (BBT), decompressive craniectomy (DC), and extreme hyperventilation are utilized. However, none of them has proven efficacy. Indomethacin (INDO), a non-steroidal anti-inflammatory drug, may be an option with an acceptable safety profile and easy to administer. Reported series showed encouraging results. We herein present a case of refractory IH after sTBI in which INDO was utilized. In refractory IH, INDO can help to decrease ICP and improve cerebral perfusion pressure. However, it requires administration under strict protocol since it's not free of adverse effects after withdrawal.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Bull Emerg Trauma Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Irã

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: Bull Emerg Trauma Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Argentina País de publicação: Irã