Your browser doesn't support javascript.
loading
Synthesis of novel 7-aryl and 7-spiropyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine derivatives and their study as AChE inhibitors.
Acosta, Paola; Insuasty, Braulio; Abonia, Rodrigo; Gutierrez, Margarita; Quiroga, Jairo.
Afiliação
  • Acosta P; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A. 25360, Cali, Colombia.
  • Insuasty B; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A. 25360, Cali, Colombia.
  • Abonia R; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A. 25360, Cali, Colombia.
  • Gutierrez M; Organic Synthesis Laboratory and Biological Activity (LSO-Act-Bio), Institute of Chemistry of Natural Resources, Universidad de Talca, Casilla 747, Talca, Chile.
  • Quiroga J; Heterocyclic Compounds Research Group, Department of Chemistry, Universidad del Valle, A.A. 25360, Cali, Colombia. jairo.quiroga@correounivalle.edu.co.
Mol Divers ; 21(4): 943-955, 2017 11.
Article em En | MEDLINE | ID: mdl-28785929
An efficient route for the synthesis of novel 7-aryl and 7-spiropyrazolo[4[Formula: see text],3[Formula: see text]:5,6]pyrido[2,3-d]pyrimidine derivatives is described. These compounds were obtained by a cyclocondensation reaction between pyrazolopyridinediamines 4 and aldehydes 5 or cyclic ketones 6 in the presence of acetic acid as catalyst. This procedure provides the desired compounds in good yields under a simple two-step methodology. The obtained compounds were evaluated as AChE inhibitors and showed weak AChe inhibition with [Formula: see text].
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Pirazóis / Pirimidinas / Compostos de Espiro / Inibidores da Colinesterase Limite: Animals Idioma: En Revista: Mol Divers Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Holanda
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Pirazóis / Pirimidinas / Compostos de Espiro / Inibidores da Colinesterase Limite: Animals Idioma: En Revista: Mol Divers Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Colômbia País de publicação: Holanda