Resolution of inflammation, n-3 fatty acid supplementation and Alzheimer disease: A narrative review.
J Neuroimmunol
; 310: 111-119, 2017 09 15.
Article
em En
| MEDLINE
| ID: mdl-28778434
In patients with Alzheimer's disease (AD), a persistent and unresolved neuroinflammatory process can contribute to neuronal loss and a decline in their cognitive and functional abilities. Recent studies have demonstrated that the ability to resolve inflammation is impaired in the brains of patients with AD. Preclinical evidence demonstrates the potential of therapeutic interventions on the resolution phase of inflammation in AD. Supplementation of omega-3 fatty acids (n-3 FAs), precursors for specialized pro-resolving mediators, emerged as a possibility for prevention and management of AD. Here, we provide a narrative review of resolving inflammation in AD and the role of n-3 FA supplementation in AD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
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Suplementos Nutricionais
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Encefalite
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Doença de Alzheimer
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Holanda