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Economic evaluation of outpatient parenteral antimicrobial therapy: a systematic review.
Psaltikidis, Eliane Molina; Silva, Everton Nunes da; Bustorff-Silva, Joaquim Murray; Moretti, Maria Luiza; Resende, Mariângela Ribeiro.
Afiliação
  • Psaltikidis EM; a Health Technology Assessment Department , Clinical Hospital of State University of Campinas , Campinas , Brazil.
  • Silva END; b School of Medical Sciences , State University of Campinas , Campinas , Brazil.
  • Bustorff-Silva JM; c Faculty of Ceilândia , University of Brasilia , Brasilia , Brazil.
  • Moretti ML; a Health Technology Assessment Department , Clinical Hospital of State University of Campinas , Campinas , Brazil.
  • Resende MR; d Surgery Department, School of Medical Sciences , State University of Campinas , Campinas , Brazil.
Expert Rev Pharmacoecon Outcomes Res ; 17(4): 355-375, 2017 Aug.
Article em En | MEDLINE | ID: mdl-28776441
INTRODUCTION: Outpatient parenteral antimicrobial therapy (OPAT) consists of providing antimicrobial therapy by parenteral infusion without hospitalization. A systematic review was performed to compare OPAT and hospitalization as health care modalities from an economic perspective. Areas covered: We identified 1455 articles using 13 electronic databases and manual searches. Two independent reviewers identified 35 studies conducted between 1978 and 2016. We observed high heterogeneity in the following: countries, infection site, OPAT strategies and outcomes analyzed. Of these, 88% had a retrospective observational design and one was a randomized trial. With respect to economic analyses, 71% of the studies considered the cost-consequences, 11% cost minimization, 6% cost-benefit, 6% cost-utility analyses and 6% cost effectiveness. Considering all 35 studies, the general OPAT cost saving was 57.19% (from -13.03% to 95.47%). Taking into consideration only high-quality studies (6 comparative studies), the cost saving declined by 16.54% (from -13.03% to 46.86%). Expert commentary: Although most studies demonstrate that OPAT is cost-effective, the magnitude of this effect is compromised by poor methodological quality and heterogeneity. Economic assessments of the issue are needed using more rigorous methodologies that include a broad range of perspectives to identify the real magnitude of economic savings in different settings and OPAT modalities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Assistência Ambulatorial / Infecções / Anti-Infecciosos Tipo de estudo: Clinical_trials / Guideline / Health_economic_evaluation / Systematic_reviews Limite: Humans Idioma: En Revista: Expert Rev Pharmacoecon Outcomes Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Assistência Ambulatorial / Infecções / Anti-Infecciosos Tipo de estudo: Clinical_trials / Guideline / Health_economic_evaluation / Systematic_reviews Limite: Humans Idioma: En Revista: Expert Rev Pharmacoecon Outcomes Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido