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Concentration of sulfated glycosaminoglycans in the mammary tissue of female rats with the aging and about hormonal influence.
Torres, Sueli M P S; Nader, Helena B; Simões, Ricardo S; Baracat, Edmund C; Simões, Manuel de J; Fuchs, Luiz F P; Soares, José Maria; Gomes, Regina Célia T.
Afiliação
  • Torres SMPS; a Histology and Structural Biology Division of the Department of Morphology and Genetics , Universidade Federal de São Paulo , São Paulo , Brazil.
  • Nader HB; b Molecular Biology Division of the Department of Biochemistry , Universidade Federal de São Paulo , São Paulo , Brazil.
  • Simões RS; c Gynecology Division of the Department of Obstetrics and Gynecology , Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil.
  • Baracat EC; c Gynecology Division of the Department of Obstetrics and Gynecology , Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil.
  • Simões MJ; a Histology and Structural Biology Division of the Department of Morphology and Genetics , Universidade Federal de São Paulo , São Paulo , Brazil.
  • Fuchs LFP; d Department of Gynecology , Universidade Federal de São Paulo , São Paulo , Brazil.
  • Soares JM; a Histology and Structural Biology Division of the Department of Morphology and Genetics , Universidade Federal de São Paulo , São Paulo , Brazil.
  • Gomes RCT; c Gynecology Division of the Department of Obstetrics and Gynecology , Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil.
Gynecol Endocrinol ; 34(1): 64-68, 2018 01.
Article em En | MEDLINE | ID: mdl-28762851
It was to evaluate the concentration of sulfate glycosaminoglycans (GAG) in mammary tissue of the young and adult female rats and ovariectomized females rats after hormonal stimulation. For this purpose, 60 female rats were divided into six groups with 10 animals/each: nonovariectomized groups: G1 (5 months), and G2 (15 months) and ovariectomized groups: OG (vehicle); EG: (estradiol, 7 days of treatment), PG (progesterone acetate, 23 days of treatment) and EPG: (estradiol (7 days of treatment) and next progesterone acetate (23 days of treatment). Twenty-four hours after the last treatment, all animals were euthanized, the mammary tissue removed, processed for biochemical evaluation and quantification of the GAG. The comparison between groups showed that the concentration dermatan sulfate (DS) G1 was lower compared to G2, OG, EG (p < .05) and G2 was lower compared to OG (p < .05), and OG was higher compared to EG, GP, EPG (p < .05); and heparan sulfate (HS) G1 was higher compared to G2 (p < .05), and G2 was higher compared to OG, EP, PG and EPG (p < .05). These changes in the extracellular matrix might explain, at least in part, hormonal influence about sulfated glycosaminoglycans in response to physiological state/age, and in response to hormonal treatment in the mammary tissues.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progesterona / Envelhecimento / Estradiol / Glicosaminoglicanos / Glândulas Mamárias Animais Limite: Animals Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Progesterona / Envelhecimento / Estradiol / Glicosaminoglicanos / Glândulas Mamárias Animais Limite: Animals Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido